… In order to assess the phenotypes of the VOCs Delta and Omicron-BA.… spike protein, we
constructed a set of recombinant SARS-CoV-2 clones containing defined mutations in the spike …

… to review the genotype, phenotype, and pathogenesis of different strains of SARS-CoV-2. …
SARS-CoV-2 variant mutation in spike protein appeared in epidemiological and clinical …

… To investigate phenotypes of individual Alpha spike substitutions, we infected hamsters
intranasally with each mutant virus, as well as with chimeric viruses containing the entire …

… alongside experiments to elucidate the phenotypic impacts of mutations. In this Review, we
summarize the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, …

… To investigate phenotypes of the 8 spike amino acid … with SARS-CoV-2 mutants encoding
each of the individual spike … 17 containing the D614G spike substitution that has become …

… Finally, we show that the spike phenotypes we measure explain much of the changes in
viral growth rate among different XBB-descended viral clades that have emerged in humans …

… b Schematic showing C.1.2 mutations on the RBD-down conformation of SARS-CoV-2
spike, with domains of a single protomer shown in cartoon view and colored cyan (N-terminal …

… Initial phenotypic characterizations of the spike D614G … particles incorporating the
SARS-CoV-2 spike protein. The … cell types, suggesting that spike G614 might be associated with …

… SARS-CoV-2 lineages have diverged into highly prevalent variants termed “variants of
concern” (VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in vitro …

… This suggests our observed transduction phenotype is independent of Spike S1 subunit …
We found significant increases in infection with SARS-CoV-2 complemented with Spike G614 at …