… people. However, the source of those T cells has been speculative. Using human blood
samples derived before the SARS-CoV-2 virus … cell epitopes across the SARS-CoV-2 genome to …

… against SARS-CoV-2 was observed in unexposed people; … characterization of SARS-CoV-2
T cell responses in humans, … unexposed donors display significant reactivity to SARS-CoV…

… Thus, there is urgent need to understand the magnitude and composition of the human CD4
+ and CD8 + T cell responses to SARS-CoV-2. If natural infection with SARS-CoV-2 elicits …

… CD4 + T cells reactive against SARS-CoV-2 can be found in unexposed individuals, and …
in response to common cold coronavirus (CCCoV) infection. Here, we utilized SARS-CoV-2-…

… of coronavirus disease 2019 (COVID-19), caused by the newly-emerged coronavirus
SARS-CoV-… Many studies are dissecting the human immune response to SARS-CoV-2 and …

… against SARS-CoV-2 and human coronavirus (HCoV… unexposed HD who donated their
blood during the pandemic as controls, so we cannot exclude a potential infection by SARS-CoV-…

… in reactive unexposed controls relative to SARS-CoV-2 convalescents, with low homology
between COVID-19 convalescent T cell epitopes and known epitopes from endemic human …

… the complexity of precursor T cell repertoire and implicate noninfectious exposures to
common microbes as a key factor that shapes human preexisting immunity to SARS-CoV-2. …

… In SARS-CoV-2-unexposed humans, cross-reactive serum antibodies were identified toward
… SARS-CoV-2-unexposed humans rarely exhibited antibody responses to the SARS-CoV-2 …

… To identify possible sources for the T-cell cross-reactivity observed in people unexposed to
SARS-CoV-2, we also performed a protein BLAST search for all 177 experimentally validated …