Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats

A Çolak, B Kelten, A Sağmanligil, O Akdemir… - Journal of Clinical …, 2008 - Elsevier
Tauroursodeoxycholic acid (TUDCA) is a biliary acid with … the therapeutic efficacy of TUDCA
in an experimental model of … , trauma only, and trauma plus TUDCA treatment) of 10 each. In …

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
… our assumption, TUDCA treatment could reduce tissue damage, … TUDCA treatment
significantly attenuates secondary injury and improves motor function recovery in SCI mice. TUDCA

Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene

Z Zhang, J Chen, F Chen, D Yu, R Li, C Lv… - Cell Stress and …, 2018 - Springer
… This study also provides a new strategy for relieving secondary damage by … of TUDCA on
motor functional recovery. Our results indicate that TUDCA effectively decreases the secondary

Effect of tauroursodeoxycholic acid on bile acid‐induced apoptosis in primary human hepatocytes

Benz, Angermüller, Otto, Sauer… - European journal of …, 2000 - Wiley Online Library
… coated to the microtitre plate and a secondary anti-DNA antibody coupled to peroxidase. From
damage induced by low bile acid concentrations of 50±100 mM GCDCA, representing the …

… of the unfolded protein response by tauroursodeoxycholic acid counteracts apoptotic cell death and fibrosis in a mouse model for secondary biliary liver fibrosis

A Paridaens, S Raevens, L Devisscher… - International Journal of …, 2017 - mdpi.com
… Lastly, we suggest that TUDCA indeed exerts its beneficial effect on liver damage and
fibrosis through alleviating CHOP-induced apoptotic cell death, as treatment with …

Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats

CMP Rodrigues, S Solá, Z Nan… - Proceedings of the …, 2003 - National Acad Sciences
… Injury is thought to arise from tissue reaction secondary to the … bile acids such as deoxycholic
acid, UDCA and TUDCA are … -like proteases, and histological damage of the peri-ICH region…

Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment

D Mantopoulos, Y Murakami, J Comander, A Thanos… - PloS one, 2011 - journals.plos.org
… may be mediated through a direct effect on damaged cells … such as growth arrest DNA
damage-inducible gene 153 (… were incubated with the secondary antibody Alexa Flour 488-…

Application of tauroursodeoxycholic acid for treatment of neurological and non-neurological diseases: is there a potential for treating traumatic brain injury?

KR Gronbeck, CMP Rodrigues, J Mahmoudi… - Neurocritical care, 2016 - Springer
damage, cerebral contusions, hematomas and/or laceration, and diffuse axonal injury.
Secondary … care setting after TBI is to reduce secondary brain injury by instituting aggressive …

[HTML][HTML] Neuroprotective effects and impact on caspase-12 expression of tauroursodeoxycholic acid after acute spinal cord injury in rats

Y Dong, L Miao, L Hei, L Lin, H Ding - International journal of …, 2015 - ncbi.nlm.nih.gov
… of secondary nerve damage after SCI. Tauroursodeoxycholic acid (TUDCA) is the main bile
acid in bear bile and is a type of ursodeoxycholic acid conjugated derivative. Studies have …

[PDF][PDF] Protective effect of tauroursodeoxycholic acid on the autophagy of nerve cells in rats with acute spinal cord injury.

L Miao, Y Dong, FB Zhou, YL Chang… - European Review for …, 2018 - europeanreview.org
Tauroursodeoxycholic acid (TUDCA) is a type of steroid … Tauroursodeoxycholic acid protects
retinal neural cells from cell death … Tauroursodeoxycholic acid and secondary damage after …