IFN-γ and TNF induce senescence and a distinct senescence-associated secretory phenotype in melanoma
L Homann, M Rentschler, E Brenner, K Böhm… - Cells, 2022 - mdpi.com
… the effector cytokines interferon-gamma (IFN-γ) and tumor … as senescence-associated
secretory phenotype (SASP). This … WM115 were treated with the cytokines IFN-γ and TNF as CIS, …
secretory phenotype (SASP). This … WM115 were treated with the cytokines IFN-γ and TNF as CIS, …
Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.
S Sad, TR Mosmann - Journal of immunology (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
… IFN-y inhibited the development of Thl-like IFN-y-secreting cells, and the combination of TGF-p
and anti-IFN… cytokine secretion phenotype in the presence of TGF-P or IL-4, respectively. …
and anti-IFN… cytokine secretion phenotype in the presence of TGF-P or IL-4, respectively. …
Interferon-α and interferon-γ differentially affect pancreatic β-cell phenotype and function
ME Baldeón, T Chun… - American Journal of …, 1998 - journals.physiology.org
… individual roles of interferon (IFN)-α and IFN-γ in β… IFN-γ but not IFN-α decreased secreted
and intracellular insulin concentrations in βTC6-F7 and βTC3 cells. Likewise, IFN-γ but not IFN…
and intracellular insulin concentrations in βTC6-F7 and βTC3 cells. Likewise, IFN-γ but not IFN…
IRF1 Mediates Growth Arrest and the Induction of a Secretory Phenotype in Alveolar Epithelial Cells in Response to Inflammatory Cytokines IFNγ/TNFα
… the contribution of single and combined inflammatory cytokines IFNγ, TNFα, IL-1β and IL-6
on growth arrest and on the secretory phenotype of A549 alveolar epithelial cells; in addition, …
on growth arrest and on the secretory phenotype of A549 alveolar epithelial cells; in addition, …
IFN-gamma and TNF-alpha as a priming strategy to enhance the immunomodulatory capacity of secretomes from menstrual blood-derived stromal cells
… phenotype and secretome content of MenSCs. Our results revealed that the optimal condition
for priming MenSCs was the combination of interferon gamma (IFNγ) … after IFNγ and TNFα …
for priming MenSCs was the combination of interferon gamma (IFNγ) … after IFNγ and TNFα …
The senescence-associated secretory phenotype: the dark side of tumor suppression
JP Coppé, PY Desprez, A Krtolica… - Annual review of …, 2010 - annualreviews.org
… The most significant of these effects is the acquisition of a senescence-associated secretory
phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the …
phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the …
Effects of temporal IFNγ exposure on macrophage phenotype and secretory profile: exploring GMP-Compliant production of a novel subtype of regulatory …
K Zitta, L Hummitzsch, F Lichte, F Fändrich… - Journal of Translational …, 2024 - Springer
… by temporally altering IFNγ administration while adhering to the established GMP-compliant
protocol. The here presented findings indicate that early IFNγ administration during the …
protocol. The here presented findings indicate that early IFNγ administration during the …
Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-γ-and …
FAW Verreck, T de Boer… - Journal of leukocyte …, 2006 - academic.oup.com
… the phenotypic and functional profiles of Mφ-1 and Mφ-2 in response to microbial antigens
and interferon-γ (IFN-γ) … Activated IL-23 + /IL-12 + Mφ-1 secreted IL-1β, IL-18, IL-6, and tumor …
and interferon-γ (IFN-γ) … Activated IL-23 + /IL-12 + Mφ-1 secreted IL-1β, IL-18, IL-6, and tumor …
T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen
EN Bou Ghanem, CC Nelson… - The Journal of …, 2011 - journals.aai.org
… In both strains of mice, the vast majority of the memory phenotype CD8 + T cells that rapidly
secreted IFN-γ expressed low levels of CD49d on the cell surface (Fig. 8B). Because the …
secreted IFN-γ expressed low levels of CD49d on the cell surface (Fig. 8B). Because the …
Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN and TNF-α in human peripheral blood
E Hagiwara, F Abbasi, G Mor, Y Ishigatsubo… - Cytokine, 1995 - Elsevier
… IL-2, IL-4 and IFN, suggesting that the cells secreting these factors were regulated indepen…
that IL-2 and IFN were secreted by cells with distinct phenotypes. This series of findings …
that IL-2 and IFN were secreted by cells with distinct phenotypes. This series of findings …
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