… Because the senescent phenotype is variable and depends on the cell type and the … senesce
after UV and the cell-specific mechanisms they use to maintain the senescent phenotype, …

… analysis on primary mouse keratinocytes undergoing oncogene-induced senescence (OIS) …
As expected, senescent keratinocytes exhibited hallmark features of senescence, including …

… senescence associated secretory phenotype, including HSP60, which localizes to the surface
of EVs. Finally, EVs from senescent … Our results highlight senescence changes in epithelial …

… Although keratinocytes and melanocytes have typically displayed similar responses and
comparable results when subjected to identical experimental conditions, this caveat must be …

… evidence that senescent cells, through the senescence-associated secretory phenotype (…
, but the control of its activity in the senescence programme has not been elucidated. IL-1 …

… on cell-specific aging and senescent phenotypes of fibroblasts and keratinocytes and the
impact … oxidation, telomere shortening, a secretory phenotype and survival within the tissue) of …

… into keratinocytes. We have previously shown that mice whose melanocytes or keratinocytes
… In cell culture the Atg7 deficient melanocytes were prone to premature senescence and …

… how cellular senescence and the senescence-associated secretory phenotype (SASP) …
In order to better distinguish between senescent cell populations that are beneficial versus …

… senescent cells, we treated normal (NOK805) and dysplastic (D6) senescent oral keratinocytes
… First, we wanted to assess whether Y-27632 was able to rescue senescent keratinocytes …

… senescence permanently arrests cell proliferation, often accompanied by a multi-faceted
senescence-associated secretory phenotype (… and stimulated keratinocyte differentiation in cell …