The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
B Ritschka, M Storer, A Mas, F Heinzmann… - Genes & …, 2017 - genesdev.cshlp.org
… SASP can promote tissue regeneration. However, prolonged exposure leads to a subsequent
cell-intrinsic arrest, likely as a tumor-suppressive response to aberrant regeneration. This …
cell-intrinsic arrest, likely as a tumor-suppressive response to aberrant regeneration. This …
The senescence-associated secretory phenotype and its regulation
S Lopes-Paciencia, E Saint-Germain, MC Rowell… - Cytokine, 2019 - Elsevier
… The senescence-associated secretory phenotype (SASP) defines the ability of senescent …
, limits fibrosis and promotes wound healing and tissue regeneration. On the other hand, the …
, limits fibrosis and promotes wound healing and tissue regeneration. On the other hand, the …
[HTML][HTML] Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products
NIM Fadilah, MSMAK Jailani… - Journal of Tissue …, 2022 - ncbi.nlm.nih.gov
… and tissue regenerative agents secreted by the stem cells that will satisfy regulatory
requirements. This is because the cell’s secreted … The most common secreted factors found in …
requirements. This is because the cell’s secreted … The most common secreted factors found in …
Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products
NI Md Fadilah… - Journal of Tissue …, 2022 - journals.sagepub.com
… and tissue regenerative agents secreted by the stem cells that will satisfy regulatory
requirements. This is because the cell’s secreted … The most common secreted factors found in …
requirements. This is because the cell’s secreted … The most common secreted factors found in …
Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration
MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
… Functional MSC-EV cargo and MSC secreted soluble factors potentially mediating tissue
repair. MSCs secrete soluble factors and EVs that promote tissue regeneration through a …
repair. MSCs secrete soluble factors and EVs that promote tissue regeneration through a …
Tissue‐mimetic culture enhances mesenchymal stem cell secretome capacity to improve regenerative activity of keratinocytes and fibroblasts in vitro
JG Hodge, HE Decker, JL Robinson… - … and Regeneration, 2023 - Wiley Online Library
… of wound healing and tissue regeneration in a variety of settings. However, the role of a
tissue-mimetic hydrogel culture system in augmenting the MSC secretory response is still under …
tissue-mimetic hydrogel culture system in augmenting the MSC secretory response is still under …
Diabetes-induced cellular senescence and senescence-associated secretory phenotype impair cardiac regeneration and function independently of age
… regeneration. We assessed the hypothesis that senescence and senescence-associated
secretory phenotype (… regenerative/reparative defect imposed by DM. We obtained cardiac …
secretory phenotype (… regenerative/reparative defect imposed by DM. We obtained cardiac …
Characterization of a Vimentinhigh/Nestinhigh proteome and tissue regenerative secretome generated by human pancreas-derived mesenchymal stromal cells
… , the foundational knowledge acquired in this study will support future investigation comparing
the unique regenerative secretory potential of tissue-specific MSC populations in vivo. …
the unique regenerative secretory potential of tissue-specific MSC populations in vivo. …
Mesenchymal stromal cells as critical contributors to tissue regeneration
GD Sagaradze, NA Basalova, AY Efimenko… - Frontiers in cell and …, 2020 - frontiersin.org
… In addition, these cells acquire a senescence-associated secretory phenotype (SASP)
involving the secretion of factors that can affect the behavior of neighboring cells via autocrine/…
involving the secretion of factors that can affect the behavior of neighboring cells via autocrine/…
The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases
L Cuollo, F Antonangeli, A Santoni, A Soriani - Biology, 2020 - mdpi.com
… of SASP have been less investigated, including tissue remodeling factors and growth
factors, which are presumably important for tissue regeneration. This may represent a caveat in …
factors, which are presumably important for tissue regeneration. This may represent a caveat in …
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