… SASP can promote tissue regeneration. However, prolonged exposure leads to a subsequent
cell-intrinsic arrest, likely as a tumor-suppressive response to aberrant regeneration. This …

… The senescence-associated secretory phenotype (SASP) defines the ability of senescent …
, limits fibrosis and promotes wound healing and tissue regeneration. On the other hand, the …

… and tissue regenerative agents secreted by the stem cells that will satisfy regulatory
requirements. This is because the cell’s secreted … The most common secreted factors found in …

… and tissue regenerative agents secreted by the stem cells that will satisfy regulatory
requirements. This is because the cell’s secreted … The most common secreted factors found in …

… Functional MSC-EV cargo and MSC secreted soluble factors potentially mediating tissue
repair. MSCs secrete soluble factors and EVs that promote tissue regeneration through a …

… of wound healing and tissue regeneration in a variety of settings. However, the role of a
tissue-mimetic hydrogel culture system in augmenting the MSC secretory response is still under …

… regeneration. We assessed the hypothesis that senescence and senescence-associated
secretory phenotype (… regenerative/reparative defect imposed by DM. We obtained cardiac …

… , the foundational knowledge acquired in this study will support future investigation comparing
the unique regenerative secretory potential of tissue-specific MSC populations in vivo. …

… In addition, these cells acquire a senescence-associated secretory phenotype (SASP)
involving the secretion of factors that can affect the behavior of neighboring cells via autocrine/…

… of SASP have been less investigated, including tissue remodeling factors and growth
factors, which are presumably important for tissue regeneration. This may represent a caveat in …