Supramolecular nanoassembly of lysozyme and α-lactalbumin (apo α-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells

P Somu, S Paul - Colloids and Surfaces B: Biointerfaces, 2019 - Elsevier
… protein nanoassembly of lysozyme and bovine α lactalbumin (SN LYZ-BLA ) with a mean
size of 55 nm and demonstrated its selective cytotoxicity as well as potential curcumin delivery …

Stable self-assembly of bovine α-lactalbumin exhibits target-specific antiproliferative activity in multiple cancer cells

S Mahanta, S Paul - ACS Applied Materials & Interfaces, 2015 - ACS Publications
… , we prepared self-assembled α-lactalbumin that exhibits strong … of cytotoxicity from GTD,
we performed the cytotoxicity study of GTD. We found that 0.1% GTD did not show any cytotoxic

The alpha-lactalbumin/oleic acid complex and its cytotoxic activity

M Jøhnke, TE Petersen - Milk protein, 2012 - books.google.com
… The protein alpha-lactalbumin (α-LA) is present in the … cytotoxic activity against cells
with an apparent selectivity for cancer cells. The complex is called HAMLET (Human α-lactalbumin

[HTML][HTML] The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component

Y Delgado, M Morales-Cruz, CM Figueroa… - FEBS open bio, 2015 - Elsevier
… contributions of OA and α-LA to the cytotoxicity of HAMLET and HAMLET-like complexes. …
that HAMLET-like complexes are selectively cytotoxic by activating caspase-independent …

The cytotoxicity of fatty acid/αlactalbumin complexes depends on the amount and type of fatty acid

CR Brinkmann, A Brodkorb, S Thiel… - European Journal of …, 2013 - Wiley Online Library
… : Cytotoxic complexes of α-lactalbumin and several different fatty acids could be produced.
The cytotoxicity … acid 2, suggesting that the apoptotic effect of the complex was sterio selective. …

α-Lactalbumin, amazing calcium-binding protein

EA Permyakov - Biomolecules, 2020 - mdpi.com
… Complexes of partially unfolded α-LA with oleic acid are cytotoxic to various tumor and
bacterial cells. α-LA in the cytotoxic complexes plays a role of a delivery carrier of cytotoxic fatty …

α-Lactalbumin forms with oleic acid a high molecular weight complex displaying cytotoxic activity

B Spolaore, O Pinato, M Canton, M Zambonin… - Biochemistry, 2010 - ACS Publications
selective death of tumor cells. However, the mechanism by which this complex kills a wide
range of tumor cell lines is as yet largely unknown. The difficulty in rationalizing the cytotoxic

Cytotoxicity of apo bovine α-lactalbumin complexed with La3+ on cancer cells supported by its high resolution crystal structure

DS Yarramala, P Prakash, DS Ranade, S Doshi… - Scientific Reports, 2019 - nature.com
… There are massive demands for compounds to selectively kill … cytotoxicity of La 3+ -B-α-LA
against cancer cells is through apoptotic path way. The higher anticancer activity of La 3+ -B-α-…

Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes

T Nakamura, T Aizawa, R Kariya, S Okada… - Journal of Biological …, 2013 - ASBMB
… Although HAMLET (human α-lactalbumin made lethal to tumor cells), a complex formed by
human α-lactalbumin and oleic acid, has a unique apoptotic activity for the selective killing of …

The toxicity of bovine αlactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer‐derived …

CR Brinkmann, CW Heegaard, TE Petersen… - The FEBS …, 2011 - Wiley Online Library
… is cytotoxic by itself and that, in contrast to the literature, a complex of α-lactalbumin and oleic
acid has cytotoxic … tumor selectivity of the α-LA:OA complex by testing the cytotoxicity of the …