Supramolecular nanoassembly of lysozyme and α-lactalbumin (apo α-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells
… protein nanoassembly of lysozyme and bovine α lactalbumin (SN LYZ-BLA ) with a mean
size of 55 nm and demonstrated its selective cytotoxicity as well as potential curcumin delivery …
size of 55 nm and demonstrated its selective cytotoxicity as well as potential curcumin delivery …
Stable self-assembly of bovine α-lactalbumin exhibits target-specific antiproliferative activity in multiple cancer cells
… , we prepared self-assembled α-lactalbumin that exhibits strong … of cytotoxicity from GTD,
we performed the cytotoxicity study of GTD. We found that 0.1% GTD did not show any cytotoxic …
we performed the cytotoxicity study of GTD. We found that 0.1% GTD did not show any cytotoxic …
The alpha-lactalbumin/oleic acid complex and its cytotoxic activity
M Jøhnke, TE Petersen - Milk protein, 2012 - books.google.com
… The protein alpha-lactalbumin (α-LA) is present in the … cytotoxic activity against cells
with an apparent selectivity for cancer cells. The complex is called HAMLET (Human α-lactalbumin …
with an apparent selectivity for cancer cells. The complex is called HAMLET (Human α-lactalbumin …
[HTML][HTML] The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component
Y Delgado, M Morales-Cruz, CM Figueroa… - FEBS open bio, 2015 - Elsevier
… contributions of OA and α-LA to the cytotoxicity of HAMLET and HAMLET-like complexes. …
that HAMLET-like complexes are selectively cytotoxic by activating caspase-independent …
that HAMLET-like complexes are selectively cytotoxic by activating caspase-independent …
The cytotoxicity of fatty acid/α‐lactalbumin complexes depends on the amount and type of fatty acid
CR Brinkmann, A Brodkorb, S Thiel… - European Journal of …, 2013 - Wiley Online Library
… : Cytotoxic complexes of α-lactalbumin and several different fatty acids could be produced.
The cytotoxicity … acid 2, suggesting that the apoptotic effect of the complex was sterio selective. …
The cytotoxicity … acid 2, suggesting that the apoptotic effect of the complex was sterio selective. …
α-Lactalbumin, amazing calcium-binding protein
EA Permyakov - Biomolecules, 2020 - mdpi.com
… Complexes of partially unfolded α-LA with oleic acid are cytotoxic to various tumor and
bacterial cells. α-LA in the cytotoxic complexes plays a role of a delivery carrier of cytotoxic fatty …
bacterial cells. α-LA in the cytotoxic complexes plays a role of a delivery carrier of cytotoxic fatty …
α-Lactalbumin forms with oleic acid a high molecular weight complex displaying cytotoxic activity
B Spolaore, O Pinato, M Canton, M Zambonin… - Biochemistry, 2010 - ACS Publications
… selective death of tumor cells. However, the mechanism by which this complex kills a wide
range of tumor cell lines is as yet largely unknown. The difficulty in rationalizing the cytotoxic …
range of tumor cell lines is as yet largely unknown. The difficulty in rationalizing the cytotoxic …
Cytotoxicity of apo bovine α-lactalbumin complexed with La3+ on cancer cells supported by its high resolution crystal structure
… There are massive demands for compounds to selectively kill … cytotoxicity of La 3+ -B-α-LA
against cancer cells is through apoptotic path way. The higher anticancer activity of La 3+ -B-α-…
against cancer cells is through apoptotic path way. The higher anticancer activity of La 3+ -B-α-…
Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes
T Nakamura, T Aizawa, R Kariya, S Okada… - Journal of Biological …, 2013 - ASBMB
… Although HAMLET (human α-lactalbumin made lethal to tumor cells), a complex formed by
human α-lactalbumin and oleic acid, has a unique apoptotic activity for the selective killing of …
human α-lactalbumin and oleic acid, has a unique apoptotic activity for the selective killing of …
The toxicity of bovine α‐lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer‐derived …
CR Brinkmann, CW Heegaard, TE Petersen… - The FEBS …, 2011 - Wiley Online Library
… is cytotoxic by itself and that, in contrast to the literature, a complex of α-lactalbumin and oleic
acid has cytotoxic … tumor selectivity of the α-LA:OA complex by testing the cytotoxicity of the …
acid has cytotoxic … tumor selectivity of the α-LA:OA complex by testing the cytotoxicity of the …
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