… the dyslipidemia commonly observed in insulin resistant states characterized by HTG, …
animal models, hepatic VLDL overproduction occurs in insulin resistant humans 17 and in …

… Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to
suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly …

… -selective hepatic insulin resistance hypothesis. In humans, hepatic DNL and insulin resistance
travel together: Hepatic … increased in subjects with peripheral insulin resistance (47,48). …

… Here, we show that ‘selective insulin resistance’ is caused by the differential expression of
Irs1 … We demonstrate that hepatic Irs2-knockout mice develop ‘selective insulin resistance’, …

… insulin and reduced amplitude of insulin … hepatic control of glucose and lipid by insulin,
according to which delayed aPKC switch-off contributes to selective hepatic insulin resistance, …

… causes hepatic insulin resistance selective to hepatic glycogen … for insulin resistance. (HEPATOLOGY
2013;57:2213-2223) … fatty liver disease (NAFLD) and insulin resistance are …

… insulin can still regulate lipid metabolism; hepatic glucose metabolism that bypasses insulin’s
… understanding of insulin’s action in governing different aspects of hepatic lipid metabolism …

… diminished, and insulin signaling in muscle, glucose … , hepatic ceramide accumulates in
response to CNS-dependent dietary excess irrespective of fat content; hepatic insulin resistance …

… between hepatic lipid accumulation and hepatic insulin resistance and … impairs insulin
signalling, in the pathogenesis of lipid-induced … a model of selective hepatic insulin resistance and …

… sensitivity, to limit liver lipid deposition, and to prevent insulin suppression of liver … -selective
insulin resistance by promoting insulin action on glucose metabolism but limiting hepatic …