Selective loss of estrogen receptor β in malignant human colon

EF Foley, AA Jazaeri, MA Shupnik, O Jazaeri, LW Rice - Cancer Research, 2000 - AACR
estrogen replacement therapy on colon cancer. The estrogen receptor (ER) is required for the
action of estrogen… and transcriptional response to selective estrogen response modulators. …

Therapeutic potential of selective estrogen receptor modulators

JÅ Gustafsson - Current opinion in chemical biology, 1998 - Elsevier
… one estrogen receptor and that an estrogenic agent was definitively categorized as an estrogen
… More recently we have learnt that there are two estrogen receptors which, under certain …

Selective estrogen receptor modulation: concept and consequences in cancer

VC Jordan - Cancer cell, 2004 - cell.com
… site-specific actions of the selective estrogen receptor modulators tamoxifen and raloxifene.
The known beneficial or negative actions of selective estrogen receptor modulators (SERMs) …

Selective estrogen receptor modulation: a personal perspective

VC Jordan - Cancer research, 2001 - AACR
… Wolf DM, Jordan VC The estrogen receptor from a tamoxifen stimulated MCF-… estrogen
receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor

Selective estrogen receptor modulators: an alternative to hormone replacement therapy

HU Bryant, WH Dere - Proceedings of the Society for …, 1998 - journals.sagepub.com
estrogen receptor, agents displaying this tissue selective profile were later classified as
selective estrogen receptor … a distinct pharmacological profile from full estrogens (ie, ICI- 164,384…

Selective estrogen receptor modulators: structure, function, and clinical use

CK Osborne, H Zhao, SAW Fuqua - Journal of clinical oncology, 2000 - ascopubs.org
estrogen that are mediated through the estrogen receptor (ER). However, these drugs also
have many estrogenic … are more appropriately called selective estrogen receptor modulators (…

The use of selective estrogen receptor modulators and selective estrogen receptor down-regulators in breast cancer

SJ Howell, SRD Johnston, A Howell - Best practice & research Clinical …, 2004 - Elsevier
… of agents: the selective estrogen receptorselective estrogen receptor down-regulators
(SERDs; eg fulvestrant (ICI 182780), SR 16234 and ZK 191703) also termed ‘pure anti-estrogens’…

Beyond estrogen: advances in tissue selective estrogen complexes and selective estrogen receptor modulators

JV Pinkerton, EA Conner - Climacteric, 2019 - Taylor & Francis
… to treat resistant estrogen receptor-positive breast cancer in women. Estetrol is an estrogen
… and initially considered a weak estrogen, but it appears to have dual weak estrogenic/anti-…

Selective estrogen receptor modulators: tissue specificity and clinical utility

S Martinkovich, D Shah, SL Planey… - Clinical interventions in …, 2014 - Taylor & Francis
Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target gene-…

Selective estrogen receptor modulators (SERMS)

A Diez-Perez - Arquivos Brasileiros de Endocrinologia & Metabologia, 2006 - SciELO Brasil
… , estrogen and SERMS exert different effects on estrogen … Although the mechanism of
activation of estrogen receptor is … of selective "a la carte" ligands for different hormone receptors. …