Selective replication of coronavirus genomes that express nucleocapsid protein

B Schelle, N Karl, B Ludewig, SG Siddell… - Journal of virology, 2005 - Am Soc Microbiol
… in vector RNA replication. And finally, by constructing and monitoring the replication of
recombinant, … that sustained expression of the N protein facilitates replication of the genomic RNA. …

Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle

Y Cong, M Ulasli, H Schepers, M Mauthe… - Journal of …, 2020 - Am Soc Microbiol
… A selective N protein variant carrying point mutations in these two regions fails to bind nsp3
in vitro, resulting in inhibition of its recruitment to RTCs in vivo. Furthermore, in contrast to the …

Nucleocapsid protein expression facilitates coronavirus replication

B Schelle, N Karl, B Ludewig, SG Siddell… - The Nidoviruses: Toward …, 2006 - Springer
protein mRNA in the HCoV-229E genome, we could demonstrate selective replication of
genomes that are able to express the N protein. Therefore, we conclude that the coronavirus N …

PABPC4 broadly inhibits coronavirus replication by degrading nucleocapsid protein through selective autophagy

Y Jiao, N Kong, H Wang, D Sun, S Dong… - Microbiology …, 2021 - Am Soc Microbiol
… antiviral responses and suppressing viral replication. This study demonstrated that the host
protein, PABPC4, interacts with the nucleocapsid (N) proteins from eight CoVs covering four …

An interaction between the nucleocapsid protein and a component of the replicase-transcriptase complex is crucial for the infectivity of coronavirus genomic RNA

KR Hurst, R Ye, SJ Goebel, P Jayaraman… - Journal of …, 2010 - Am Soc Microbiol
… amino-terminal segment of nsp3 bound selectively to N protein from infected cells, and
this … in some critical function for viral replication that could be provided by MHV N protein. …

BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy

N Kong, T Shan, H Wang, Y Jiao, Y Zuo, L Li, W Tong… - Autophagy, 2020 - Taylor & Francis
… In this study, we showed that BST2, an intrinsic antiviral protein, inhibited PEDV replication
by targeting and degrading the PEDV N protein through selective autophagy. Upon PEDV …

Coronavirus nucleocapsid protein facilitates template switching and is required for efficient transcription

S Zúniga, JLG Cruz, I Sola, PA Mateos-Gómez… - Journal of …, 2010 - Am Soc Microbiol
protein has RNA chaperone activity and facilitates template switching in vitro. Moreover, the
role of N protein in vivo in TGEV replicationprotein is not essential for TGEV RNA replication

The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication

S Tylor, A Andonov, T Cutts, J Cao… - Canadian journal of …, 2009 - cdnsciencepub.com
… In conclusion, we have identified that the SR-rich motif of SARS-CoV nucleocapsid protein
is important for the replication of the virus, especially on the transcription of the viral genome. …

The nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells

L Cui, H Wang, Y Ji, J Yang, S Xu, X Huang… - Journal of …, 2015 - Am Soc Microbiol
… expression of SARS-CoV N protein could promote MHV replication in RNAi-active cells but
protein cannot enhance the specific selective packaging of MHV gRNA to facilitate the MHV …

[HTML][HTML] Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication

BA Chau, V Chen, AW Cochrane, LJ Parent… - Cell Reports, 2023 - cell.com
… roles in virus replication, among which is … nucleocapsid proteins and how their intrinsic
abilities to condense through liquid-liquid phase separation (LLPS) contribute to viral replication. …