… selectivity of p38 family proteins, however, remain mostly unknown, which may be critical for
understanding broad activities of p38 MAPK … that a tumor suppressing role of the p38 stress …

… p38 MAPK. More recently, Bhaskar’s group reported that a recently reported selective p38α
MAPK direct inhibitor 8 [78] suppresses … , novel p38 MAPK inhibitors with improved selectivity …

… Loss of p38 MAPK activation in the mutant cells was … that p38 MAPK is regulated by the
coordinated and selective actions of … of p38 MAPK in wild-type cells, but strongly suppressed p38 …

… We found that activation of the p38 MAPK pathway in … suppress pSTAT1 and pp38 MAPK
levels in M1 macrophages. This observation prompted us to test whether activated p38 MAPK …

… the specificity of p38 MAPK signaling: (i) selective docking interactions between the MAPKK
and p38 MAPK; and (ii) sequences within the activation loop (T-loop) of individual p38 MAP …

… , leading to selective enhancement or suppression of particular inflammatory responses. …
results in vacuolization and cell death with suppression of the hypertrophic responses. In a …

… We observed that pretreatment with Dex suppressed p38 MAPK phosphorylation in the
control macrophages during both phases (Figure 3B). Densitometric analysis revealed that Dex-…

… Although the connection between deregulation of p38 MAPK … role of p38 MAPK in tumor
suppression has involved … cells defective in p38 MAPK may still be under selective pressure to …

… , such as MKK3 and MKK6, seemed to be elevated, or phosphatase activity towards
phospho-p38 MAP kinase might have been suppressed in the macrophages after LPS- and …

… of pyridinylimidazole drugs [CSBP (cytokine-suppressive anti-inflammatory drug-binding …
It has been also reported that the selectivity of the interaction between MAP2Ks and MAPKs …