… p38 isoform, p38β-2, and more than 5000-fold selectivity over … SB-681323 is also highly
selective for p38 when compared … p38 MAPK signaling, and this translated into suppression of …

… 3 Selective inhibition of the p38 MAPK pathway by Wip1 in vivo. (A) Wip1 selectively inhibits
the p38 MAPK … Thus, while Wip1 strongly suppressed p38 activation in vivo, no significant …

… Its mode of action was later found to be entirely novel – SB203580 is an ATP-competitive
inhibitor of p38 MAPK suppressing the activation of MAPK-activated protein kinase 2 (MK2) …

… p38 activity is suppressed in … p38 activity was significantly suppressed, as were markers of
DNA repair, suggesting that these cells have resolved the DNA damage stress leading to p38 …

… The p38 MAPK protein kinases affect a variety of intracellular responses, with well-…
Furthermore, we discuss how the p38 MAPK pathway might be best exploited for the development of …

… roles of p38 MAPK-α and -β because it selectively inhibits these isoforms without affecting …
In order to confirm the effect of SB203580 on c-Src activity is due to suppression of p38 MAPK, …

… suppress the cytokines tumor necrosis factor-α and interleukin-1. The potential of p38 MAPK
… inhibitor compounds tested were partly attributed to poor drug target selectivity resulting in …

… Therefore, MKK3 inhibition could selectively suppress inflammation while sparing some …
The determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem 2003;…

… , highlighting the crucial role of p38 MAPK suppression in their pharmacological actions. In
… these ginsenosides to p38 MAPK. The results obtained proposed p38 MAPK involvement in …

… To further examine whether stress-induced TEAD inhibition selectively suppresses YAP-driven
cancer cell growth, we compared a series of UM cell lines with mutations in either GNAQ …