… of T-cell self-tolerance in the … cell tolerance, which includes T-cell receptor (TCR) self-reactivity,
costimulation, cytokines, and antigen presentation by a variety of antigen-presenting cells …

… -antigen throughout their development. We … in tolerance to systemic and organ-specific
self-antigens. We also touch upon the factors that may lead to the breakdown of self-tolerance …

… with receptors against antigens not represented intrathymically will mature and join the … T
cell pool. They may either ignore self-antigens expressed by tissues unable to activate T cells …

… T cell population encountering its corresponding antigen expressed … tolerance induction in
mice expressing the Kb antigen … Finally, we compare the basis of tolerance in these two types …

… cells bearing anti-self receptors. This process is referred to as the acquisition of self-tolerance…
explore the mechanisms by which self-tolerance takes place, are the subject of this review. …

… T cells … self tolerance of these cells depends on a continuous or recurrent interaction with
the selecting ligand or cross-reactive self-antigens, resulting in the dynamic tuning of cellular …

… that isolated molecular and cellular defects entail deleterious … and maintenance of tolerance
to self antigens. Thus, immune … of self-reactive, potentially autoaggressive, B and T cells. …

… cells in vitro. Thus, it appears that clonal anergy may be one way to render T cells tolerant
to self-antigens which are encountered only after the T cells have matured and left the thymus. …

… cell tolerance to self antigens is at least partly a reflection of clonal deletion of immature T cells
… This article provides an overview of self tolerance of T cells and centers on the critical role …

… self components. Most solutions to this self-tolerance problem are cell intrinsic and involve
the deletion or inactivation of autoreactive cells. However, an extrinsic form of dominant …