… and detection for ALP activity, we designed and … activity, our probe has many
advantages (Table S1 in Supporting Information). Particularly, the probe harbors a novel self-immolative …

… (HP) was designed based on ESIPT for trapping ALP activity in cells and in vivo. Notably,
incorporating a self-immolative spacer dramatically reduces the response time (8.5 min) of HP. …

… ALP activity (Scheme 1) and successfully applied it to live cell imaging. The probe APW
adopts a self-immolative … reported ratio probes for detecting ALP activity, our probe has many …

… the self-immolative mechanism [40], YJ was designed in which an ALP unit incorporating a
self-immolative p-cresol spacer … of electron transfer and self-immolative processes occurred to …

… Eventually a fluorogenic probe containing a self-immolative spacer that was alkaline
phosphatase (ALP) sensitive was implemented for the quantitative analysis of ALP activity (entry 7, …

… Self-immolative spacers in these chemosensors not only facilitate the linkage of designed
… screening of ALP inhibitors and real-time monitoring of intracellular phosphatase activities. …

… In conclusion, two new self-immolative linear polymers based on alternating cyclization
and elimination reactions were successfully designed and synthesized. Synthetically, it was …

… action, is linearly correlated with the amount of target molecule released. We believe that
further studies in this direction will lead to self-immolative … that the activity-based self-immolative …

… ) was used as the light-responsive, self-immolative spacer. An advantage of this linker is
the … hapten with an alkaline phosphatase (AP)-sensitive self-immolative caging group (Scheme …

… Several groups have reported the introduction of self-immolative linkers to … activity.17, 18,
19 We will introduce two representative examples targeting ALP (alkaline phosphatase) and β-…