… our knowledge of whether senescent cells contribute to organismal aging and age-related …
senescent cells, representing a major advance in aging biology and geriatric medicine. …

… increasingly posed by global aging. In the past decades, longer human lives benefiting from
improved healthcare and innovative medications have generated a global burden of late-life …

… with mitochondrial dysfunction, like those present with aging, cause global increases in
senescent cell burden that are associated with increases in frailty and multimorbidity and that …

… in the treatment of aging and age‐related diseases. Here, we describe how senescent
cells develop, the experimental evidence that causally implicates senescent cells in age‐related …

… senescence burden and other types of age-related damage. Finally, we propose a model on
the role of aging-related damage accumulation and the rate of aging … global changes in cell/…

… therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
… Despite the link between senescent cells and organismal aging, senescence and aging …

… Cellular models of HGPS and cellular senescence of fibroblasts have proven to be relevant
models for organismal aging. … roles of heterochromatin in cellular aging and SAHF formation. …

… Here, we present a framework encompassing the causes and role of senescent cells in …
This global stress could drive cellular senescence in various cell types such as fibroblasts, …

… remove senescent cells in animal models of aging offer proof-… with aging, especially those
with heavy senescent cell burden … in primary aging processes that may be distinct from cellular …

… senescent cells impairs tissue function and promotes aging. In addition, senescent cells
display senescence associated secretory phenotype (SASP), which may result in aging-related …