Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging
Y Sun, Q Li, JL Kirkland - Life Medicine, 2022 - academic.oup.com
… senescence in human non-senescent cells and amplifies the SASP in human senescent cells
via … is up-regulated in human senescent compared to non-senescent cells [54]. Importantly, …
via … is up-regulated in human senescent compared to non-senescent cells [54]. Importantly, …
Senolytic therapies for healthy longevity
JM van Deursen - Science, 2019 - science.org
… proliferation, but it decreases the health of the old by littering tissues with dysfunctional
senescent cells (SNCs). In mice, the selective elimination of SNCs (senolysis) extends median …
senescent cells (SNCs). In mice, the selective elimination of SNCs (senolysis) extends median …
Targeting senescent cells for a healthier aging: challenges and opportunities
S Song, T Tchkonia, J Jiang, JL Kirkland… - Advanced …, 2020 - Wiley Online Library
… cell cycle arrest after experiencing inherent or environmental stresses. Although cellular
senescence is … advances in specifically targeting senescent cells to improve healthy aging, or …
senescence is … advances in specifically targeting senescent cells to improve healthy aging, or …
Cellular senescence in ageing, age-related disease and longevity
E Sikora, A Bielak-Zmijewska… - Current vascular …, 2014 - ingentaconnect.com
… Senescent cells are characterized by several features including … senescent cells undergoing
either replicative senescence or … , seem to be a promising strategy for prolonging healthy …
either replicative senescence or … , seem to be a promising strategy for prolonging healthy …
Biology of healthy aging and longevity
JJ Carmona, S Michan - Revista de investigacion clinica, 2016 - medigraphic.com
… with premature aging phenotypes, including cellular senescence, inflammation, cardiac …
essential for protecting against senescence, diseases, and for promoting healthy longevity. …
essential for protecting against senescence, diseases, and for promoting healthy longevity. …
Immune system, cell senescence, aging and longevity-inflamm-aging reappraised
S Salvioli, D Monti, C Lanzarini, M Conte… - Current …, 2013 - ingentaconnect.com
… It is not known whether in longliving people there is an accumulation of senescent cells,
as … cells from healthy elderly and centenarians. Mech Ageing Dev 2000; 121: 239-50. …
as … cells from healthy elderly and centenarians. Mech Ageing Dev 2000; 121: 239-50. …
Senolytic drugs: reducing senescent cell viability to extend health span
PD Robbins, D Jurk, S Khosla… - Annual review of …, 2021 - annualreviews.org
… The rat closely recapitulates human physiology and pathophysiology and can be used to
study aspects of aging, including longevity, senescence-related pathology, and pharmacologic …
study aspects of aging, including longevity, senescence-related pathology, and pharmacologic …
A senescence-centric view of aging: implications for longevity and disease
M Borghesan, WMH Hoogaars, M Varela-Eirin… - Trends in cell …, 2020 - cell.com
… We describe mechanisms by which senescent cells drive aging and diseases, and we discuss
… Consistently, in a young healthy individual senescent cells can be induced successfully …
… Consistently, in a young healthy individual senescent cells can be induced successfully …
Immune clearance of senescent cells to combat ageing and chronic diseases
P Song, J An, MH Zou - Cells, 2020 - mdpi.com
… These immune signatures of supercentenarians well explain that the increased healthy
longevity is due to immunosurveillance of some conditions such as infections [128] and tumor …
longevity is due to immunosurveillance of some conditions such as infections [128] and tumor …
Extending human healthspan and longevity: a symposium report
LM DeVito, N Barzilai, AM Cuervo… - Annals of the New …, 2022 - Wiley Online Library
… senescent cells from the body. Selectively targeting p16 Ink4a -positive senescent cells for
… related accumulation of senescent cells, suggesting that senescent immune cells could be a …
… related accumulation of senescent cells, suggesting that senescent immune cells could be a …