… human healthspan. Here, we review molecular links between cellular senescence and
age-… avenues that may be exploited to target senescent cells in future geriatric medicine. …

… of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related …
is not a main contributor to age-related increases in senescent cells, or that chronically …

… of senescence to emphasize how senescent cells are currently … further compounded by the
senescent cell secretome. Finally, … for targeting various types of senescent cells as well as the …

… we can replicate in vitro the age-related changes that occur in human cells in vivo. In this …
Moreover, recent results confirm that the chromosome ends of senescent cells contribute to the …

… The aim is to understand how cell senescence affects human aging and disease, separating
… Virally transformed senescent cells reactivate DNA synthesis and divide even with critically …

… senescent cells in human tissues as a function of age. In this report, we describe the design
of human … ) tissue sections spanning 10 major organs and three age groups – Young (13-35 …

… or cellular senescence. This article reviews what is known about cell senescence and its role
in the aging of … Because senescent cells accumulate with age in human skin, and secrete …

… that report these senescence-associated changes in various aging cells and … age-related
changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells …

… senescent cells can be used to reconstitute normal young human tissue when the cell aging
… ), we may be able to prevent or treat human age-related disease in a more effective and …

… Cells with similar characteristics accumulate during normal aging as well as in younger persons
infected with human … of replicative senescence is not an artifact of cell culture but is also …