… of senescence to emphasize how senescent cells are currently … further compounded by the
senescent cell secretome. Finally, … for targeting various types of senescent cells as well as the …

… human disease. One plausible explanation for this correlation is that mechanisms that drive
ageing might also promote age-related diseases. … on two major human diseases of ageing, …

… extending human healthspan. Here, we review molecular links between cellular senescence
and … avenues that may be exploited to target senescent cells in future geriatric medicine. …

… of senescent cells to human disease and to explore the preventive and therapeutic effects of
clearing senescent cells by … for chronic age-related human diseases with INK-ATTAC mice. …

… , and induction of senescence in neighbouring cells (paracrine senescence). An … cells that
develop key properties of senescent cells might contribute to ageing and age-related disease …

… Here, we review the evidence that cellular senescence drives … for disease and driving
established disease forward. Hence, the growing field of senotherapy (neutralizing senescent cells …

… -related diseases. Current therapies are focused on elimination of senescent cell functions in
… such as cancer and arthrosis [83], which are aging-related diseases where senescent cells …

… diseases and therefore a potential therapeutic target. Here, the role of senescent cells in
age-related diseases is … The mechanisms leading to senescent cells are presented, including …

… of senescent cells are challenging tasks that limit our understanding of the role of senescent
cells in diseases … senescent cells in tissues on a single-cell basis. The method combines a …

… The ubiquity of disease is no more ordained than is the rarity … how diseases of aging occur,
that we may prevent human … Virally transformed senescent cells reactivate DNA synthesis …