… In this study, we evaluated the therapeutic potential of the senolytic drug combination …
age-dependent disc degeneration. Additionally, we determined whether disc health outcomes vary …

… from the degenerative IVD, … senolytic drug can effectively treat senescence-associated IVDD.
This approach can be extended to treat other types of senescence-associated degenerative …

… senescent disc cells and alleviating IVDD; finally, we provide a table listing senolytic
drugs and small molecules, aiming to propose potential drugs for IVDD therapy in the future. …

… senolytic effect has antioxidant and anti-inflammatory properties. We compared the effect of
o-Vanillin to RG-7112, a pure senolytic drug, … We also aimed to establish if one or both drugs …

… Intervertebral disc degeneration (IDD) represents major … disc degeneration (IDD) has been
reported to be the primary cause of low back pain 2 , with limited effective therapeutic drugs …

… identifies novel senolytic drugs for the treatment of IVD degeneration. Senolytic drugs could
… provide a better quality of life of patients living with IVDs degeneration and low back pain. …

… This study aimed to determine if combining the two senolytic drugs, o-Vanillin and RG-7112, …
with the degree of disc degeneration and pain [13,14]. Overloading intact disc and IVD cells …

… pain and disc degeneration was used for monolayer and pellet culture experiments. …
senescent cells is a direct indication that a potential drug has senolytic properties. Since senolytics …

Intervertebral disc degeneration (IVDD) refers to the aging and degenerative diseases of
intervertebral disc components such as nucleus pulposus, annulus fibrosus, and cartilage …

… a class of drugs that … disc degeneration, the results of this study are now confined to females.
Third, in terms of imaging, only Micro-CT was used to evaluate the degeneration of the disc, …