… Keap1 regulates the activity of Nrf2 and acts as a sensor for … the molecular mechanisms by
which the Keap1–Nrf2 system … the multiple stress-sensing mechanisms of Keap1 and novel …

… of the association between Keap1 and Nrf2, which has greatly enhanced our understanding
of the molecular mechanisms involved in the regulation of the Keap1–Nrf2 system. Recently …

… the expression levels of Keap1 and Nrf2 were regulated to … multiple cysteine sensor system
for the Keap1-Nrf2 system, … mutant of Keap1 against a variety of Nrf2 inducers exploiting the …

… Nrf2 and other signaling pathways, which provides new insights into the mechanisms by which
the Keap1–Nrf2 system … We have identified Keap1 as a sensor of electrophiles and ROS, …

… KEAP1-NRF2 system. We discuss the molecular mechanisms by which the KEAP1-NRF2
system … and the roles the system plays in organismal defense mechanisms. We consider the …

… activities in relieving Keap1-mediated Nrf2 degradation. … Keap1-Nrf2 system senses signals
of a variety of electrophiles by disparate mechanisms, and yet all of the signals lead to Nrf2 …

… While Nrf2 is often referred to as the “master regulator of the oxidative stress response,” the
… O 2 sensor in the Keap1-Nrf2 system is unknown. Due to the central role that the Keap1-Nrf2 …

… factor 2 (Nrf2) and the central hub for sensing endogenous and … overview of the mechanisms
by which Keap1 orchestrates the … of pharmacological targeting of the Keap1-Nrf2 system. …

… the KEAP1-NRF2 system and its relation to intractable cancers with massive NRF2 activation.
… Additional studies on the sensing mechanisms will advance our understanding of the …

… While we exploited the human KEAP1-NRF2 system for the above … system to mouse
Keap1-Nrf2 for our extended analyses to examine how these novel substitutions affect Keap1's …