Effect of the NK3 receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans

LA Houghton, F Cremonini, M Camilleri… - …, 2007 - Wiley Online Library
… , are expressed in the motor and sensory systems of the digestive tract. The aim of this study
… NK 3 receptor antagonist, talnetant (SB223412) with placebo on rectal sensory function and …

Effects of a serotonin 5-HT4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans

AE Bharucha, M Camilleri, S Haydock, I Ferber… - Gut, 2000 - gut.bmj.com
… of SB-207266 as a 5-HT 4 receptor antagonist in healthy subjects receiving a 5-HT 4 agonist…
-HT 4 receptors in regulating gastrointestinal transit, colonic motor, and sensory functions in …

Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome

Y Sagami, Y Shimada, J Tayama, T Nomura, M Satake… - Gut, 2004 - gut.bmj.com
… CRH receptor antagonist, α-helical CRH 9–41 (αhCRH). … 10 On the other hand, accelerated
colonic motor function can … and blocked by treatment with a variety of CRH antagonists. …

NK1 (substance P) receptor antagonists–why are they not analgesic in humans?

R Hill - Trends in pharmacological sciences, 2000 - cell.com
… By contrast, in preclinical studies in animals NK 1 receptor antagonists have … receptor
antagonists appear able to block behavioural responses to noxious and other stressful sensory

CGRP receptor antagonism and migraine

L Edvinsson, TW Ho - Neurotherapeutics, 2010 - Elsevier
… The trigeminovascular system37, 40 has a primary involvement in cranial sensory functions,
but also acts as a vasodilator pathway with antidromic release of CGRP, putatively as a …

Effects of the substance P receptor antagonist CP-96,345 on renal sensory receptor activation

UC Kopp, LA Smith - American Journal of Physiology …, 1993 - journals.physiology.org
… of SP suggest a physiological role for SP in renal sensory receptor activation. These … Our
findings showing the presence of renal sensory receptors in the renal pelvic area responsive to …

Effects of tropisetron, a 5-HT3 receptor antagonist, on proximal gastric motor and sensory function in nonulcer dyspepsia

S Klatt, W Böck, J Rentschler, K Beckh, G Adler - Digestion, 1999 - karger.com
… 5-HT 3 receptor antagonists have been shown to inhibit … of 5-HT 3 receptor antagonists
have not been studied on … of NUD and 5-HT 3 receptors to be involved in this process, our …

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

PM Zygmunt, J Petersson, DA Andersson, H Chuang… - Nature, 1999 - nature.com
… , we examined the effect of capsazepine, a competitive vanilloid receptor antagonist 6 , 7 ,
on … Figure 4: Effect of the vanilloid receptor antagonist capsazepine on relaxations elicited by …

Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo

PK Eide, E Jørum, A Stubhaug, J Bremnes, H Breivik - Pain, 1994 - Elsevier
… Pain and sensory thresholds were examined before and after intravenous administration
of … Post-herpetic neuralgia was associated with impaired sensory function. as shown by …

Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin

S Bevan, S Hothi, G Hughes, IF James… - British journal of …, 1992 - Wiley Online Library
… 1 Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin.
The present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …