High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines
T Calandra, J Gerain, D Heumann… - The American journal of …, 1991 - Elsevier
… of IL-6 in 70 patients with septic shock to determine if circulating levels of IL-6 were detectable
in these patients, to follow the evolution of IL-6 levels during the course of septic shock, …
in these patients, to follow the evolution of IL-6 levels during the course of septic shock, …
Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma
C Martin, C Boisson, M Haccoun… - Critical care …, 1997 - journals.lww.com
… evolution of TNF-alpha and IL-6 in septic shock and in multiple trauma patients. During the
course of septic shock… alpha and considerably higher concentrations of IL-6 are detected. This …
course of septic shock… alpha and considerably higher concentrations of IL-6 are detected. This …
Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses
J Briegel, M Jochum, C Gippner-Steppert… - Journal of the …, 2001 - journals.lww.com
… Little is known regarding the evolution of the cytokine response in human septic shock in the
presence of hypercortisolemia induced by infusion of stress doses of hydrocortisone. Twenty…
presence of hypercortisolemia induced by infusion of stress doses of hydrocortisone. Twenty…
Evolution of plasminogen activator inhibitor type 1 in patients with septic shock—correlation with cytokine concentrations
EKO Kruithof, T Calandra, G Pralong, D Heumann… - Fibrinolysis, 1993 - Elsevier
… -1 contributes to the pathogenesis of septic shock. In fact, … septic shock, PAIlevels correlate
strongly with TNFa and IL-6. PAIand IL-6 are very elevated in the early stage of septic shock…
strongly with TNFa and IL-6. PAIand IL-6 are very elevated in the early stage of septic shock…
[HTML][HTML] Critical advances in septicemia and septic shock
UN Das - Critical care, 2000 - Springer
… innate immune system release cytokines and express certain … system in that it is highly
evolved, specific in its responses … of sepsis and septic shock, including IL-1, IL-2, IL-6, IL-8, TNF…
evolved, specific in its responses … of sepsis and septic shock, including IL-1, IL-2, IL-6, IL-8, TNF…
[HTML][HTML] Molecular mechanisms in septic shock
… , MDS), a proinflammatory cytokine. The consequence of these processes is the decrease
in cardiac flow and peripheral vasoconstriction, the evolution being towards the hyperdynamic …
in cardiac flow and peripheral vasoconstriction, the evolution being towards the hyperdynamic …
Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock
A Pachot, G Monneret, N Voirin, P Leissner, F Venet… - Clinical …, 2005 - Elsevier
… blood and to study their prognostic values in septic shock patients. At the onset of shock,
compared to healthy volunteers, mRNA levels in septic shock patients were increased for IL-10, …
compared to healthy volunteers, mRNA levels in septic shock patients were increased for IL-10, …
Prognostic values of serum cytokines in septic shock
C Martin, P Saux, JL Mege, G Perrin, L Papazian… - Intensive care …, 1994 - Springer
… strongly contrasts with the evolution of TNFa concentrations. … that IL-6 peaks near the onset
of septic shock and rapidly declines thereafter, in contrast to TNF~ No prognostic value of IL-6 …
of septic shock and rapidly declines thereafter, in contrast to TNF~ No prognostic value of IL-6 …
Cytokine storms, evolution and COVID-19
J Alcock, A Masters - Evolution, medicine, and public health, 2021 - academic.oup.com
… Some pharmaceutical interventions under study for COVID-19 have analogs that were
previously used to treat sepsis and septic shock, with the guiding hypothesis that restraining …
previously used to treat sepsis and septic shock, with the guiding hypothesis that restraining …
The pathophysiology of septic shock
OO Nduka, JE Parrillo - Critical Care Nursing Clinics, 2011 - ccnursing.theclinics.com
… This definition evolved to describe widespread circulatory dysfunction following injury. … ,
characterized by a markedly imbalanced cytokine response with resultant tissue injury. In contrast…
characterized by a markedly imbalanced cytokine response with resultant tissue injury. In contrast…
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