… -level resistance in the strains analyzed in this study. Out of all PZA resistant strains three
carried the pncA wild type sequence. … genes are also important for mediating PZA resistance. …

… basis of their patterns of drug-resistance mutations. The numbers of … sequence and the
estimated level of drug resistance for that sequence according to the HIVDB genotypic resistance …

… mechanisms described so far implicated changes in gene copy numbers or transcripts
levels, whole genome sequencing is beginning to reveal a role for point mutations in …

… isolates to ten anti-TB drugs; for pyrazinamide, we used BACTEC MGIT 960. We determined
the accuracy of WGS by comparing the prevalence of drug resistance, measured by WGS, …

… data in the context of the diagnosis of drug resistance is low-level phenotypic resistance.
Some mutations confer ‘low-level’ resistance in MTBC, resulting in ambiguous results from …

… length of time required to obtain a drug resistance profile. Traditionally, diagnosing drug
resistant TB (DR-TB) in clinical samples requires phenotypic drug susceptibility testing (DST). …

… sequences, we were able to predict quantitative drug resistance levels for the majority of drug
resistance … Predicting quantitative levels of drug resistance by whole-genome sequencing …

… fbiC were found in phenotypically resistant cases, while all the … drugs. In conclusion, we
present a comprehensive panel of gene mutations linked to different levels of drug resistance …

… Population-level surveys were done in hospitals and clinics … the use of genetic sequencing
to estimate the resistance of … each drug, we assessed the accuracy of genetic sequencing …

… gyrA and gyrB confer resistance to fluoroquinolones, albeit not at the same level, with
MOX … , in contract with the higher levels of resistance observed for OFX and ciprofloxacin [50]. …