… Sequence variants in PLA2R1 observed in the present study (95 patients with iMN) Of the 18
variants … These 9 variants were all encountered in a heterozygous state in one patient each, …

… private variants in the coding sequence … Membranous Nephropathy consortium sequenced
the PLA2R1 exons and exon-intron boundaries of 90 patients with membranous nephropathy …

… An HLA-DR3 association with membranous nephropathy (… strong genetic association,
sequencing of the 30 PLA2R1 … sequenced by Sanger sequencing and all observed variants, …

… risk allele for MN and IgA nephropathy, another autoimmune kidney disease. This is consistent
with the fact that previous GWAS of IgA nephropathy have highlighted other associated …

… via the immunization of rats with kidney extracts (Heymann nephritis rats) in 1959 [9]; this …
as the antigen for membranous glomerulonephritis developed in Heymann nephritis rats [10]. …

… in the serum of patients with membranous lupus nephritis and IgA nephropathy. Recently, von
… Interaction between PLA2R1 and HLA-DQA1 Variants contributes to the increased genetic …

… Interestingly, modeling sequence variants of PLA2R1 had little effect on T cell epitope
prediction, suggesting that coding variants in PLA2R1 are less likely to alter the immunogenicity of …

… in patients with idiopathic membranous nephropathy (iMN) … European cohorts, and sequenced
these exons using genomic DNA … and HLA-DQA1 sequence variants among the 3 groups. …

… Therefore, we hypothesized that sequence variations in the TRPC6 gene could affect …
sequence variants in the coding region of the TRPC6 gene (Table 2). Of the eight coding variants …

… Further studies did not detect mutations or rare variants in the sequence and the splice
sites of PLA2R1 (ref. ). Thus, it is unlikely that the immune reaction is triggered by a change in …