… In the blinded validation study reported here, we evaluated NGS in the diagnostic setting
for mutational analysis of 113 samples from non-small cell lung cancer (NSCLC), colorectal …

… The analysis of somatic mutations across multiple genes in cancer specimens may be used
to aid … The analytical validation of targeted next-generation sequencing panels is important to …

… and can help inform diagnosis, prognosis, … ‘somatic’ NGS panels, because all cells in a
person's body contain germline DNA, including tumors. As a result, these panels not only detect …

… profiling of solid tumors, to detect variants of clinical importance for … Both NGS panels and
platforms as used in this study demonstrated comparable performance in detection of somatic …

… This study provides a somatic mutation detection algorithm using a machine learning approach.
We trained our method using in silico mutations spiked into replicate exome sequencing …

… three somatic variant callers, we found that Strelka2 detected more … sequencing with Strelka2
analysis is useful for detection of accurate somatic mutations in cancer gene panel testing. …

… Somatic mutation analysis of 173 genes using in 2,433 breast tumors identified 13,084
somatic mutations which were predicted to affect protein sequence [13]. Another study identified …

… of the significance of the detected alterations. The case study … analysis in somatic NGS
gene panel assays, but also the limitations of using NGS panels to detect CNVs in somatic …

… Other somatic mutations, such as those of the TSHR gene, have been reported in some …
-generation sequencing as a new approach for testing a broad spectrum of point mutations that …

… sequencing (NGS) panels. This review summarises the diagnostic and prognostic value of
somatic mutation testing … in myeloid NGS panels that are designed for somatic mutations, but …