Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study

JJ Bazarian, P Biberthaler, RD Welch… - The Lancet …, 2018 - thelancet.com
… , non-penetrating TBI and a Glasgow Coma … GFAP were measured in serum and analysed
using prespecified cutoff values of 327 pg/mL and 22 pg/mL, respectively. UCH-L1 and GFAP

ALERT-TBI study on biomarkers for TBI: has science suffered?

AIR Maas, HF Lingsma - The Lancet Neurology, 2018 - thelancet.com
Serum GFAP and UCH1-L1 in prediction of absence of intracranial injuries on head CT (ALERT-TBI
test] as an aid in the evaluation of suspected traumatic brain injury (Glasgow Coma …

Blood biomarkers on admission in acute traumatic brain injury: relations to severity, CT findings and care path in the CENTER-TBI study

E Czeiter, K Amrein, BY Gravesteijn, F Lecky… - …, 2020 - thelancet.com
… Our results support the further development of serum GFAP assays towards implementation
… Absolute GFAP levels in our study were much higher than those reported in the ALERT-TBI

Comparing glial fibrillary acidic protein (GFAP) in serum and plasma following mild traumatic brain injury in older adults

NA Huebschmann, TM Luoto, JE Karr… - Frontiers in …, 2020 - frontiersin.org
… We hypothesized that plasma and serum GFAP levels would (i) be highly correlated, (ii)
have similar ability to discriminate between those with and without acute traumatic intracranial …

… value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI …

FK Korley, S Jain, X Sun, AM Puccio, JK Yue… - The Lancet …, 2022 - thelancet.com
… Furthermore, in patients presenting with traumatic brain injury and a GCS score of 3–12,
incorporating GFAP and UCH-L1 values into the IMPACT models significantly increases the …

Predictive performance of traumatic brain injury biomarkers in high-risk elderly patients

MD Ward, A Weber, VRD Merrill… - The journal of …, 2020 - academic.oup.com
… We also noted significantly higher serum UCH-L1 and GFAP values among elderly patients
… The main ALERT-TBI study was not designed to examine only those ≥65 years of age and …

Diagnostic accuracy of prehospital serum S100B and GFAP in patients with mild traumatic brain injury: a prospective observational multicenter cohort study–“the …

SC Seidenfaden, JL Kjerulff, N Juul… - Scandinavian journal of …, 2021 - Springer
Serum GFAP concentration was measured after one freeze-thaw cycle using a commercial
Human GFAP enzyme-linked immunosorbent assay (ELISA), according to the manufacturer’s …

Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury

EB Button, WH Cheng, C Barron, H Cheung… - Alzheimer's Research & …, 2021 - Springer
… Many other studies have supported these findings using various assays and analytical
platforms [5,6,7] and show that post-TBI serum and plasma GFAP levels can predict magnetic …

Early GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and …

JL Sperry, JF Luther, DO Okonkwo, LE Vincent… - Journal of …, 2024 - thejns.org
Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI):
a multicentre observational study. Lancet Neurol. 2018; 17(9): 782-789. …

… and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury

L Papa, GM Brophy, RD Welch, LM Lewis… - JAMA …, 2016 - jamanetwork.com
TBI. This study evaluated the temporal profiles of serum glial and neuronal serum biomarkers
GFAP … (ED) with and without mild to moderate TBI (MMTBI) and assessed their diagnostic …