… patients with severe hemophilia. This article will review potential modifiers of hemophilia-…
and complications in hemophilic patients considered to have severe hemophilia. These …

… arthropathy is observed among patients with severe hemophilia. Studies have … patients
with severe hemophilia. Of special interest are some 10% of the patients with severe hemophilia …

… with severe hemophilia should be … patient characteristics, the effect of postponing prophylaxis
on long-term arthropathy was studied in a cohort of 76 patients with severe hemophilia …

… This article reviews the literature on possible determinants of phenotypic variation in patients
with severe hemophilia. Apart from the well-recognized associations of the level of residual …

… with severe hemophilia have reduced BMD. Patients at risk are those with signs of hemophilic
… may complicate the future treatment of patients with hemophilia, screening of patients with …

… of hemophilic arthropathy demonstrated that the severity of the arthropathy increased with
age and degree of coagulation defect. All patients over 5 years of age with severe hemophilia …

… Patients with severe hemophilia generally exhibit a severe bleeding phenotype with … mild
hemophilia (FVIII:C/FIX:C > 5 IU/dL). Patients with severe hemophilia exhibit the most severe …

… primarily for patients with moderate and severe hemophilia B … to change the landscape in
hemophilia B by reducing … 50% of all hemophilia patients and up to 90% of severe hemophilia …

… phenotype of severe hemophilia A (HA) is influenced by co-inheritance with the factor V
G1691A mutation. We therefore investigated 124 pediatric PUP patients with hemophilia (A: n = …

… Advanced ankle arthropathy is common in severely hemophilic patients by early adulthood.
Abutting anterior exostoses on the tibia and talus develop and often are associated with an …