Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells
… Shc family of proteins differed between DRG and PC12 cells. … in DRG neurons and PC12
cells. The predominantly expressed … and 52 kDa proteins whereas those in PC12 cells were the …
cells. The predominantly expressed … and 52 kDa proteins whereas those in PC12 cells were the …
Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells
D Thomas, SD Patterson, RA Bradshaw - Journal of Biological Chemistry, 1995 - ASBMB
… PC12 cells consistently contained a 43-kDa protein that was associated with Shc, a signal-transducing
protein … (GST)-Shc fusion protein, the 43-kDa protein was identified as actin by …
protein … (GST)-Shc fusion protein, the 43-kDa protein was identified as actin by …
… Factor-induced Mitogen-activated Protein Kinase Activation in 293T Cells and Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells: IDENTIFICATION OF A …
D Thomas, RA Bradshaw - Journal of Biological Chemistry, 1997 - ASBMB
… For EGF-induced mitogen-activated protein kinase activation in 293T cells, both Shc PTB …
engagement with Shc may exist. For NGF-induced neurite outgrowth in PC12 cells, Shc PTB …
engagement with Shc may exist. For NGF-induced neurite outgrowth in PC12 cells, Shc PTB …
c-Src and phosphatidylinositol 3-kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells
K Sato, T Otsuki, M Kimoto, M Kakumoto… - Biochemical and …, 1998 - Elsevier
… It has also been demonstrated that PC12 cells expressing mutant Shc proteins in which
tyrosine residue 239/240 is substituted by phenylalanine could not undergo neurite outgrowth in …
tyrosine residue 239/240 is substituted by phenylalanine could not undergo neurite outgrowth in …
[HTML][HTML] Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells.
M Ohmichi, K Matuoka, T Takenawa… - Journal of Biological …, 1994 - Elsevier
… Shc proteins, and their associationwith the tyrosine PI-3P phosphorylated receptors in PC-12
cells… lin to activate this pathway in PC-12 cells, we analyzed the tyrosine phosphorylation of …
cells… lin to activate this pathway in PC-12 cells, we analyzed the tyrosine phosphorylation of …
[HTML][HTML] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
J Degoutin, M Vigny, JY Gouzi - FEBS letters, 2007 - Elsevier
… To address the question of the potential association of the adaptor proteins FRS2 and
Shc with ALK, we first performed co-immunoprecipitation experiments in HEK 293 …
Shc with ALK, we first performed co-immunoprecipitation experiments in HEK 293 …
NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway
L Lu, C Annerén, KA Reedquist, JL Bos… - Experimental cell research, 2000 - Elsevier
… These effects could not be explained by altered signaling through the phospholipase C-,
Shc, or FGF receptor substrate-2 (FRS2) pathways or by influences on ERK activation, and it …
Shc, or FGF receptor substrate-2 (FRS2) pathways or by influences on ERK activation, and it …
Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells
S Tanaka, S Hattori, T Kurata… - … and cellular biology, 1993 - Am Soc Microbiol
… Recently, Rozakis-Adcock et al. reported that the neuronal differentiation of PC12 cells
induced by Shc, an SH2-containing protein, was also inhibited by the dominantnegative mutant …
induced by Shc, an SH2-containing protein, was also inhibited by the dominantnegative mutant …
Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells
DS Min, BH Ahn, DJ Rhie, SH Yoon, SJ Hahn… - …, 2001 - Elsevier
… Therefore, the possibility that during differentiation of PC12 cells, Shc proteins may interact
… either anti-Shc or anti-PLD1 antibodies. Interestingly, we have found that the Shc proteins (66…
… either anti-Shc or anti-PLD1 antibodies. Interestingly, we have found that the Shc proteins (66…
Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain (∗)
I Dikic, AG Batzer, P Blaikie, A Obermeier… - Journal of Biological …, 1995 - ASBMB
… of Shc with the activated NGF receptor (TrkA), we used parental PC12 cells and PC12 cells
… In these studies, we were not able to use full-length GST-Shc protein since it was rapidly …
… In these studies, we were not able to use full-length GST-Shc protein since it was rapidly …
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