The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct
phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal …

… SHC proteins on biological responses in SHCtransfected fibroblasts. We found that the
expression of exogenous SHC proteins … of exogenous SHC proteins. These results illustrate that …

… One such pathway involves the Shc adaptor proteins. Shc proteins are part of a diverse
family of proteins encoded by at least three separate genes, shcA, shcB, andshcC ( …

… ; Figure 1) by proteins containing motifs known as Src homology-2 (… regulation by
protein–tyrosine kinases (PTKs) and protein–… In the latter case, Shc and Grb2 protein interactions …

… homology 2 (SH2) domain in the carboxyl terminus of the protein and a phosphotyrosine …
microinjected glutathioneS-transferase fusion proteins of either the Shc PTB or SH2 domains …

… tyrosine kinase contains other structural features that modify its transforming activity, including
an N-terminal myristoylation site (5) and noncatalytic Src homology 2 and 3 (SH2 and SH3…

… possesses at least three tyrosine phosphorylation sites in its central collagen-homology
domain and two phosphotyrosine-binding domains, one SH2 domain in the carboxyl terminus …

… The Src homologous and collagen-like (SHC) protein plays an essential role in signal …
activation of the protein Ras. The crystal structure of the SH2 domain of SHC has been determined …

… -containing proteins. When applied to SH2D1A/SAP (SLAM-associated protein), a protein
whose … a number of novel interacting proteins for this disease-associated protein. SMALI also …

… The SHC protein is also phosphorylated on tyrosine and is recognized by the SH2 … from
proteins of the Src family and from ZAP-70 family of PTK as well as from the adaptor protein SHC …