[HTML][HTML] Insulin-induced phosphorylation of the 46-and 52-kDa Shc proteins.
GJ Pronk, J McGlade, G Pelicci, T Pawson… - Journal of Biological …, 1993 - Elsevier
… Shc proteins are targets for the activated insulin receptor tyrosine kinase. Here we show that
the 46- and 52-kDa Shc proteins … of a 23-kDa protein with the Shc proteins. These effects on …
the 46- and 52-kDa Shc proteins … of a 23-kDa protein with the Shc proteins. These effects on …
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
S Okada, AW Kao, BP Ceresa, P Blaikie… - Journal of Biological …, 1997 - ASBMB
… One important proximal target for the EGF receptor was originally identified as a series of
proteins (66, 52, and 46 kDa), termed Shc for Srchomology 2/α-collagen related ( …
proteins (66, 52, and 46 kDa), termed Shc for Srchomology 2/α-collagen related ( …
Interaction of Shc with Adaptor Protein Adaptins (∗)
Y Okabayashi, Y Sugimoto, NF Totty, J Hsuan… - Journal of Biological …, 1996 - ASBMB
… polypeptides of ~46, 52, and 66 kDa. Shc proteins of 46 and 52 kDa encoded by a 3.4-… ,
whereas a 66-kDa Shc protein is likely to be encoded by a distinct shc transcript and is absent in …
whereas a 66-kDa Shc protein is likely to be encoded by a distinct shc transcript and is absent in …
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
J Mcglade, A Cheng, G Pelicci… - Proceedings of the …, 1992 - National Acad Sciences
… a gene, shc, that encodes two overlapping proteins of 46 and 52 kDa (… -kDa Shc protein
(p66shc) has also been detected with anti-Shc antibodies and is likely encoded by a distinct shc …
(p66shc) has also been detected with anti-Shc antibodies and is likely encoded by a distinct shc …
Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2 (∗)
J VanderKuur, G Allevato, N Billestrup… - Journal of Biological …, 1995 - ASBMB
… whether SHC and Grb2 proteins … 66-, 52-, and 46-kDa SHC proteins in 3T3-F442A fibroblasts.
GH also promoted binding of GHR and JAK2 to the SH2 domain of 46/52-kDa SHC protein …
GH also promoted binding of GHR and JAK2 to the SH2 domain of 46/52-kDa SHC protein …
The functional significance of Shc in insulin signaling as a substrate of the insulin receptor
T Sasaoka, M Kobayashi - Endocrine journal, 2000 - jstage.jst.go.jp
… 52-kDa proteins are ubiquitously expressed except in the central nervous system, while the
66-kDa Shc protein is … In this review, we mainly describe the role of 46-, 52-, and 66-kDa Shc (…
66-kDa Shc protein is … In this review, we mainly describe the role of 46-, 52-, and 66-kDa Shc (…
… of nutritional state on the formation of a complex involving insulin receptor IRS-1, the 52 kDa Src homology/collagen protein (Shc) isoform and phosphatidylinositol 3 …
J Dupont, M DEROUET, J SIMON… - Biochemical …, 1998 - portlandpress.com
… three Shc isoforms (66, 52 and 46 kDa) and Shc messenger were not altered by the nutritional
state. Shc tyrosine … Importantly, Shc was immunoprecipitated by IR antibody (mostly the 52 …
state. Shc tyrosine … Importantly, Shc was immunoprecipitated by IR antibody (mostly the 52 …
Shc Isoform-specific Tyrosine Phosphorylation by the Insulin and Epidermal Growth Factor Receptors (∗)
S Okada, K Yamauchi, JE Pessin - Journal of Biological Chemistry, 1995 - ASBMB
… the purified 52-kDa Shc isoform compared with the 46-kDa Shc isoform. … Shc is the small
adapter protein Grb2, we also determined the insulin-stimulated association of the Shc proteins …
adapter protein Grb2, we also determined the insulin-stimulated association of the Shc proteins …
Signaling via Shc family adapter proteins
KS Ravichandran - Oncogene, 2001 - nature.com
… protein of 40 kDa that still contained intact CH1 and SH2 domains (albeit at lower levels);
similarly, there was only a point mutation in the PTB domain of the dShc that was studied, and …
similarly, there was only a point mutation in the PTB domain of the dShc that was studied, and …
Insulin stimulates the phosphorylation of the 66-and 52-kilodalton Shc isoforms by distinct pathways
AW Kao, SB Waters, S Okada, JE Pessin - Endocrinology, 1997 - academic.oup.com
… Although we did not detect any change in electrophoretic mobility of the 52 and 46-kDa
Shc … To directly determine the change in phosphorylation state of the Shc proteins, we next …
Shc … To directly determine the change in phosphorylation state of the Shc proteins, we next …
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