… Shc proteins are targets for the activated insulin receptor tyrosine kinase. Here we show that
the 46- and 52-kDa Shc proteins … of a 23-kDa protein with the Shc proteins. These effects on …

… One important proximal target for the EGF receptor was originally identified as a series of
proteins (66, 52, and 46 kDa), termed Shc for Srchomology 2/α-collagen related ( …

… polypeptides of ~46, 52, and 66 kDa. Shc proteins of 46 and 52 kDa encoded by a 3.4-… ,
whereas a 66-kDa Shc protein is likely to be encoded by a distinct shc transcript and is absent in …

… a gene, shc, that encodes two overlapping proteins of 46 and 52 kDa (… -kDa Shc protein
(p66shc) has also been detected with anti-Shc antibodies and is likely encoded by a distinct shc …

… whether SHC and Grb2 proteins … 66-, 52-, and 46-kDa SHC proteins in 3T3-F442A fibroblasts.
GH also promoted binding of GHR and JAK2 to the SH2 domain of 46/52-kDa SHC protein …

… 52-kDa proteins are ubiquitously expressed except in the central nervous system, while the
66-kDa Shc protein is … In this review, we mainly describe the role of 46-, 52-, and 66-kDa Shc (…

… three Shc isoforms (66, 52 and 46 kDa) and Shc messenger were not altered by the nutritional
state. Shc tyrosine … Importantly, Shc was immunoprecipitated by IR antibody (mostly the 52 …

… the purified 52-kDa Shc isoform compared with the 46-kDa Shc isoform. … Shc is the small
adapter protein Grb2, we also determined the insulin-stimulated association of the Shc proteins …

… protein of 40 kDa that still contained intact CH1 and SH2 domains (albeit at lower levels);
similarly, there was only a point mutation in the PTB domain of the dShc that was studied, and …

… Although we did not detect any change in electrophoretic mobility of the 52 and 46-kDa
Shc … To directly determine the change in phosphorylation state of the Shc proteins, we next …