… of Shc protein in growth factorinduced mitogenic signaling, we microinjected anti-Shc anti…
the function of endogenous Shc protein, followed by stimulation with growth factors (insulin, IGF…

… We found that the expression of exogenous SHC proteins results in an increased basal … of
exogenous SHC proteins. These results illustrate that SHC proteins are implicated in the MAP(…

… Unlike SHC proteins, Grb2 is not tyrosyl phosphorylated in response to growth factor stimulation.
Some tyrosyl-phosphorylated membrane receptor tyrosine kinases have been shown to …

… association of Shc with tyrosine kinases has clearly been shown only for the epidermal growth
factor receptor and the ErbB-2 receptor (21,28). In this study, we show that Shc associates …

… tyrosine-phosphorylated protein that associated with the EGFreceptor was observed. In the
present report we identify this EGFR-associated protein as SHC, 52-kDa protein with an SH2 …

… We find that expression of small t results in enhanced growth factor stimulation of Shc
phosphorylation, leading to greater downstream activation of the Ras/MAP kinase pathway and …

… Shc that has the potential to interact with growth factor receptors and other tyrosine-phosphorylated
proteins… the binding of the Shc amino terminus (hereafter referred to as Shc 1-209) in …

… We have recently identified a novel domain in Shc, encompassing amino acids 46-209 of
the p52 Shc protein, and shown that it binds to activated growth factor receptors( …

… in Response to Growth Factor Stimulation Since SHC proteins have an SH2 domain, we
considered the possibility that they interact with and are substrates for receptortyrosine kinases. …

… of Shc proteins induces the formation of a stable complex between Shc and the adaptor
protein Grb2 in growth factor stimulated and v-Src transformed cells, Shc proteins are thought to …