… the role of Shc protein in growth factorinduced mitogenic signaling, we microinjected anti-Shc
antibodies into quiescent living cells to abrogate the function of endogenous Shc protein, …

… in ShcA, a clear role for Shc in leading to mitogen activated protein kinase (MAPK) activation
… function of Shc proteins. Although Shc has also been linked to other signaling events such …

… suggests that, like other SHP-containing proteins, SHC is involved in the cytoplasmic signaling
of mitogenic stimuli. The capacity of the SHC protein to regulate cell growth was therefore …

… of Shc. Coexpression of chimeric proteins demonstrated that mitogenic signaling from Ret/ptc2
required both recruitment of Shc and subcellular localization by Enigma. Because …

… common signaling components are used by these two distinct classes of receptors. Here we
report that the adaptor protein Shc… Shc phosphorylation by thrombin or the thrombin receptor …

… Our results indicate that this interaction of PP2A with Shc is functionally important, keeping
Shc protein in a relatively non-tyrosine-phosphorylated state. Since small t antigen displaces …

… , Shc proteins provide a molecular platform for the development of the signalling complex. …
Although the participation of ROS in mitogenic signalling is well documented [134], prostate …

… proteins may serve as binding sites for Shc (18, 27, 53). We previously showed that the Shc
SH2 domain suppresses the EGF-induced mitogenesis … Shc suppresses the mitogenesis of …

… of p66Shc on mitogenic signaling. In… mitogenic signaling involves competitive inhibition
of p52Shc binding to its upstream molecular partners and sequestering Grb2/Sos in a signaling…

… the stoichiometry of the transfected proteins. Although we cannot … I mitogenic signaling, our
results indicate a crucial role for Shc. Shc proteins have been shown to mediate the mitogenic …