… , KRAS G12C (ON) and SHP2 inhibitors alone and in combination profoundly remodel the …
KRAS and SHP2 inhibition is essential for sensitizing an anti-PD-1 resistant, immune exclusive…

… site of SHP2 with high selectivity and low toxicity are under development. This paper reviews
allosteric inhibitors of SHP2 … that SHP2 inhibitor SHP099 abrogated sorafenib resistance in …

… -emergent resistance mutations, and adaptive resistance, by … Based on the critical role of
SHP2 upstream of RAS pathway, … maintain superior ERK pathway inhibition in gliomas. Here, …

… eliminating a subset of EGFRi-tolerant cells where RTK drives MAPK pathway reactivation
(49), potentially deepening response and preventing subsequent emergence of resistance. …

… adaptive induction after cotreatment with MEKi as a surrogate readout for RAS activation. We
also found that combining SHP2 and MEK inhibitors … for RTK-driven acquired resistance to …

… mediate(s) adaptive resistance may be lineage-driven (47, 48). As such, we hypothesized
that SHP2 inhibition can attenuate the RTK-dependent adaptive resistance and can enhance …

… And in vivo animal study is needed to determine the effect of SHP2 inhibition on tumor
growth treated by oxaliplatin. In summary, we have shown in this manuscript that …

… blockage of SHP2 can overcome acquired resistance to Met inhibitors in DGC cells… resistance
to Met inhibitors. Our results are supported by a recent report showing that SHP2 inhibition …

… and prevents adaptive resistance to MEK inhibitors [25,26]. The role of SHP2 in HGSOCs, …
In this study, we investigated whether combinatorial inhibition of SHP2 and PI3K is effective …

… binding modes of inhibition and optimized … SHP2 inhibitors. Structure and property based
drug design enabled the identification of protein–ligand interactions, potent cellular inhibition, …