… in BTZ-sensitive MM cells, we tried to investigate whether SHP2 inhibitors have an effect
on BTZ-resistant MM cells. Herein, we cultured RPMI-8226 and NCI-H929 over a period of 1 …

… by MEK inhibition. Our results suggest a possibility of using a combination of SHP2 inhibitor
and … SHP2 drives adaptive resistance to ERK signaling inhibition and combined targeting …

… SHP2 to suppress JAK2/STAT3 and SHP2/Grb2/PI3K/AKT signaling pathways respectively,
resulting in inhibition on anoikis resistance… interacts with SHP2 to inhibit the SHP2/Grb2/PI3K/…

… inhibition except for recent advances in selective inhibitors targeting the G12C variant. Here,
we report that selective inhibition of the protein tyrosine phosphatase, SHP2… SHP2 inhibitor, …

… report that SHP2 is an … inhibit SHP2 activity in endothelial cells, we show that SHP2 inhibits
pro‐apoptotic STAT3 and stimulates proliferative ERK1/2 signaling. Systemic SHP2 inhibition …

… of a MEK inhibitor and a SHP2 inhibitor also prevents adaptive resistance in difficult-to-treat
wild-… Because different mechanisms of resistance to allosteric or catalytic site SHP2 inhibitors …

… Collectively, these works have provided proof-of-principle that small molecule inhibitors of
SHP-2 can prevent resistance to MAPK pathway-targeting drugs in BRAF and KRAS mutant …

… of PTPN11 or pharmacological inhibition using the SHP2 inhibitor (SHP2i) TNO155. Our
studies into the signaling response to SHP2i reveal that resistance to TNO155 is partially …

… Johnson said that SHP2 inhibitor therapy “is an area of active investigation—none of the …
is, ‘Are SHP2 inhibitors something that we can add when patients develop resistance to a …

… In the context of adaptive resistance to mutant-selective inhibitors, SHP2 inhibition has the
… Here we show, using in vitro and in vivo systems, that SHP2 inhibitors have the potential to …