… Johnson said that SHP2 inhibitor therapy “is an area of active investigation—none of the …
is, ‘Are SHP2 inhibitors something that we can add when patients develop resistance to a …

… In the context of adaptive resistance to mutant-selective inhibitors, SHP2 inhibition has the
… Here we show, using in vitro and in vivo systems, that SHP2 inhibitors have the potential to …

… Given the drug resistance of reported SHP2 inhibitors, in-… SHP2 proteins may facilitate the
development of inhibitors targeting SHP2 mutations for patients with specific adaptive resistant …

… that, MAPK inhibition using MEK inhibitors (MEKi) have limited effectiveness in such tumors
due to adaptive resistance. A major mechanism of adaptive resistance involves relief of …

… These results show that Cxcl1/5 induction is a consequence of SHP2 inhibition, rather
than an off-target effect of SHP099. Allografts established with SHP099-resistant KP cells still …

… in developing adaptive resistance to MEK/ERK inhibitors (MEKi/… averting adaptive resistance
through the use of the SRC inhibitor, … adaptive resistance pathways operating through SRC. …

… Indeed, inhibition of tumor IFN signaling renders highly resistant … of SHP2 at Tyr542 can
be used as an indicator of SHP2 … of SHP2 did not reverse TGFb-mediated inhibition of IFNg-…

… prospectively identify resistance mechanisms to SHP2 inhibition, using the prototype allosteric
inhibitor SHP099, because as I discussed in this section earlier that resistance to targeted …

… and adaptive resistance … SHP2 inhibition can overcome resistance in multiple contexts of
tyrosine kinase mediated bypass signaling leading to survival in the presence of ALK inhibition…

… as for wild-type SHP2, which falls at the far tail of the inhibition curve. … the inhibition of SHP2
in the absence of the activating peptide. … may prevent the emergence of resistance mutations. …