… of SHP2 inhibition on insulin resistance. Indeed, a 2-week treatment of HFD-fed obese mice
with SHP099, an allosteric, bioavailable SHP2 inhibitor… Moreover, SHP2 inhibition correlated …

… regulated cancer stemness contributes to the drug resistance to EGFR-TKIs. In this study
we show that SHP2 inhibition sensitizes the T790M mutant LUAD to respond to Osimertinib …

… Allosteric SHP2 inhibitors are a novel class of compounds that target hyperactive Ras/…
that uncovered novel mechanisms of adaptive resistance to pharmacologic inhibition of SHP2. …

… We utilized PHPS1, a specific SHP-2 inhibitor, to investigate whether SHP-2 activation may
directly be responsible for the survival of drug-tolerant CML cells. Surprisingly, only the co-…

… resistance to the drug (34). However, only a few studies have examined the use of an SHP2
inhibitor combined with an RTK inhibitor … of SHP2 inhibitor combined with an RTK inhibitor in …

… resistant to SHP2 inhibitors. We further show that combinations of SHP2 inhibitors with other
RAS-MAPK pathway inhibitors, such … NRAS resistance to SHP2 inhibitors is reversed when …

… We next assessed the effect of SHP2 inhibition on T cell proliferation in the presence or …
This supports the hypothesis that SHP2 may enhance resistance of tumor cells to immune-…

… SHP2 allosteric inhibitors harboring this off-target activity not only suppress oncogenic RAS
signaling but also overcome drug resistance … -target activities of SHP2 allosteric inhibitors for …

… However, the underlying mechanisms of resistance to SHP2 inhibition remain unknown. The
E3 ligase SMURF2 limits TGFβ activity by ubiquitinating and targeting the TGFβ receptor for …

… In addition, SHP2 has been shown to mediate adaptive resistance to targeted therapies in …
SHP2 inhibition may represent a potential MPN therapy in both ruxolitinib naÃve and resistant …