… 1 (NF1). Furthermore, NF1 is lower in advanced and relapsed NB and NF1 loss is enriched
… SHP2 inhibition consistently blocks tumor growth in high-risk NB mouse models, revealing a …

… Our findings illuminate a critical function for SHP2 in promoting … BRAF, NF1 loss and
nucleotide-cycling oncogenic KRAS. … NF1 LOF cell lines were sensitive to SHP2 inhibition. …

… to determine whether it could more effectively inhibit ERK signaling output in … to loss of
NF1. We found that combined MEK and SHP2 inhibition was more effective than MEK inhibition …

… , pointing to a therapeutic opportunity for SHP2 inhibition in RTK-driven cancers1. … SHP2
allosteric inhibitor, RMC-4550. RMC-4550 was studied to explore whether inhibition of SHP2 …

… efficacy of MEK inhibitor is limited … SHP2, and that combined inhibition of MEK and SHP2
is effective in MPNST. However, the clinical potential of combination MEK and SHP2 inhibitors …

… inhibition of SHP2 and MEK is active in models of NF1-… body of literature in which SHP2
inhibitors have been combined with … and clinical development of SHP2 inhibitors, as well as their …

… MEK inhibitor is limited by adaptive activation of receptor tyrosine kinases and the adaptor
protein SHP2, and that combined inhibition of MEK and SHP2 is effective in MPNST. Loss of …

… MEK with SHP2 inhibition would drive robust responses in NF1 bone lesions, because SHP2
is a … MEK and SHP2 inhibition to prevent PA in the preclinical Prss56-Nf1 KO mouse model. …

… SHP2 inhibition suppresses oncogenic RAS signaling, we sought to identify a SHP2 small
molecule inhibitor… inhibition of RAS-GTP loading would offset the loss of RAS GAP activity and …

… of JMML samples have shown that NF1 functions as a tumor suppressor by … SHP-2 crystal
structure predicts that these interactions induce a conformational shift that relieves inhibition of …