… is critical for signal transduction through the MAPK pathway, linking growth factors to Ras …
Inhibition of SHP2 primarily results from the blockade of the active site in the PTP domain by …

… pathway. Therefore, we explored whether the addition of an … allosteric SHP2 inhibitor decreases
the adaptive ERK reactivation … to the versatile efficacy of SHP2 inhibition in multiple AML …

… SHP-2 activity was restored by blockage of the IL-1 receptor and inhibition of reactive …
overexpression of different SHP-2 activity mutants in endothelial cells that SHP-2 activity inversely …

… –ERK pathway through SHP2 to the extent that the MEK inhibitor … concomitant SHP2 inhibition
prevented pERK reactivation … that SHP2 inhibition is synthetic lethal with MEK inhibition in …

… Allosteric SHP2 inhibitors (SHP2i) in the clinic prevent SHP2 … INPPL1, MAP4K5, or LZTR1
deletion reactivated ERK signaling… results comport with known functions of the SHP2 pathway. …

… SHP2 also sits upstream of RAS in the MAPK pathway and … Because SHP2 critically
mediates the signaling of multiple … , we hypothesize that a SHP2 inhibitor may be effective in …

… , SHP2 inhibitors prevent the reactivation of KRAS by SHP2. To dissect the molecular mechanisms
of resistance to SHP2 inhibitors in … activates the MAPK pathway. Earlier investigations …

… that SHP2 inhibitor SHP099 abrogated sorafenib resistance in hepatocellular carcinoma
cell lines by inhibiting RTK-induced reactivation of the MEK/ERK and AKT signaling pathways […

… SHP2 inhibition decreases adaptive resistance to sorafenib by preventing the reactivation of
the MEK/ERK and AKT signaling pathways … In HCC, mTOR and SHP2 inhibition have been …

… observations that the pharmacological JAK2 inhibitor, AG490, or … In these pathways, SHP-2
appears to interact directly with the … reactivated during JAK2 dephosphorylation (10–30 min). …