… observations that the pharmacological JAK2 inhibitor, AG490, or … In these pathways, SHP-2
appears to interact directly with the … reactivated during JAK2 dephosphorylation (10–30 min). …

… “Adaptive resistance,” in which the inhibited pathway is reactivated due to induction of genes
for RTKs/RTK ligands, is a common form of intrinsic resistance to targeted agents (48, 49, …

… to MEKis by blocking ERK signaling reactivation in KRAS-mutant gastric cancer cells. … is
ubiquitously expressed and plays positive roles in the RAS-ERK pathway, either acting as a …

… SHP2 blockade reactivates the PI3K pathway. A Representative images of the
immunohistochemistry staining of 4T1 tumors from mice treated for 14 days with Vehicle, CLR457 …

… response that reactivates the complex activity … SHP2 genetic ablation and pharmacological
inhibition we observe effective reduction in MPNST cell proliferation through ERK pathways …

… phosphatase 2 (SHP2) inhibitor delayed the emergence of … pathways potentially diminish
the effect of tepotinib monotherapy, and the combination of tepotinib with an SHP2 inhibitor …

… the influence of SHP2 inhibition on conserved signaling pathways in the presence or …
reactivated HD RMC-4550–treated and –untreated samples, indicating that SHP2 inhibition …

… AKT reactivation. We found that the SHP2 inhibitor SHP099 abrogated sorafenib resistance
… RTK-induced reactivation of the MEK/ERK and AKT signaling pathways. SHP099 in com…

… prevented adaptive feedback reactivation of the RAS pathway in KRAS-mutant cancer
cell lines (44). Targeting of other signaling pathways together with SHP2 inhibition was also …

… Most clinical trials involving SHP2 inhibitors have adopted drug … progress on SHP2 allosteric
inhibitors and pathway-dependent … the reactivation of RAS and ERK1/2, SHP2 inhibitors in …