… We hypothesized a role for another RTK in sustaining or reactivating the ERK pathway in
the residual tumor cells after TKI exposure. However, a search using a phosphorylated RTK …

… commonly due to activating mutations of pathway components such as in RAS and …
reactivation of ERK is driven by ERBB or MET receptors and is therefore mediated by SHP2 ("SHP2-…

… inhibitors through reactivation of MAPK signalling. As a result of the oncogenic activity of
SHP2, several SHP2 inhibitors … if SHP2 inhibition could similarly alter BMP pathway activation. …

… To further prove that SHP2 biological function was inhibited by γ-T3 … pathway Ras is a
direct downstream component of SHP2, hence we assumed that the down-regulation of SHP2 …

… , this was suppressed when SHP2 activity was inhibited. Since SHP2 signals to activate the
RAS-ERK pathway and inhibition of SHP2 suppressed ERK reactivation in ruxolitinib treated …

… Vertical pathway combination strategies are … pathway reactivation. Src homology region
2-containing protein tyrosine phosphatase 2 (SHP2) is a key regulator of the MAPK pathway …

… The SHP2 inhibitor blocked the reactivation of receptor tyrosine kinase-derived AKT/ERK …
would greatly block this feedback pathway so that presented synergic anti-CRC effect with low-…

… -dependent signaling pathways in collagen-stimulated platelets. … After reactivating the
reversibly oxidized SHP-2 by DTT … the inhibition of NOX, ROS-dependent inactivation of SHP-2 …

… SHP-2 in MBT2 cells and reactivated Stat1 in TCC-N5 and TCC-N10 cells. AG825 inhibited
the HER-2 pathway … cells with AG825 downregulated SHP-2 and reactivated Stat1. Similar …

… the SHP2 N308D catalytic domain can be reactivated by … of signaling pathways, especially
the RAS/ERK signaling pathway that … Inhibition and reactivation of the steady-state activity of …