… higher potency for inhibition of cell viability than the KRAS G12C (OFF) inhibitor MRTX849 in
… in RAS pathway reactivation which was blocked upon coincubation with the SHP2 inhibitor …

… mutants of SHP2 may activate other signaling pathway that is … AR reactivation could partly
compensate for the loss of SHP2 … upon treatment with ACK1 and SHP2 inhibitor appears to be …

… After transfer, membranes were air-dried, reactivated with methanol, washed once with …
conclude that SHP-2 is playing an inhibitory role at the level of pathways controlling cytoskeleton …

… Multiple attempts to therapeutically target RAS directly or pathways … on SHP2, and
reactivation of downstream signals. Inhibition of both MEK and SHP2 abrogates MEK inhibitor–…

… The tyrosine phosphatase SHP2 controls the activity of pivotal signaling pathways, including
MAPK… Inhibition of ERK feedback reactivation is sustained after 48 h compared to PLX4032 …

… recent advances made with SHP2 inhibitors as a targeted therapy … of cancer treatment based
on SHP2 inhibition. An additional … due to the reactivation of the MAPK pathway for negative …

… inhibitors are being investigated for treatment of various … determine the impact of SHP2
inhibition in combination with rapamycin … re-activation of AKT, and that targeting the RAS pathway …

… would inhibit SHP2 … SHP2 activity was also attenuated in the spleen of both WT and NS
mice, strongly suggesting this therapeutic action of SFX-01 was mediated by inhibition of SHP2 …

… Protein tyrosine phosphatase SHP2 promotes RAF-to-MAPK signaling pathway and is an …
reactivates downstream signaling 6 . We further showed that pharmacologic inhibition of SHP2 …

… pathway nodes has the potential to more robustly prevent reactivation relative to inhibition
… We are currently exploring the combination of an inhibitor of an upstream node, SHP2, with …