121 天前 - … immunotherapy as well as SOS- and SHP2-inhibitors. Based on in-silico analysis
of … compensatory re-activation of HRAS, farnesylation of RHEB in the PI3K/mTOR pathway …

135 天前 - … inhibitors with drugs that target mitogen-activated protein kinase (MAPK) feedback
reactivation… to therapies targeting different pathways, eg, KRAS+ SHP2, KRAS+CDK4/6, and …

185 天前 - … that PHI-501 inhibited the phosphorylation of MEK, ERK, AKT, and SHP2 proteins in
the … that PHI-501 considerably suppressed the reactivation of pERK and pAKT. In BRAF- or …

201 天前 - … reactivation of upstream RTKs which can result in the activation of wild-type and
mutant … we provide evidence that suggests direct effects of SHP2 inhibitor on cells of the TME. …

235 天前 - … reactivated ERK upon treatment for 12 h in A549 cells, and SHP2 inhibition by JC-010a
prevented the reactivation … signaling pathways were due to its inhibition effect on SHP2. …

247 天前 - … role of SHP2 upstream of RAS pathway, we postulated that the combination of SHP2i
and BRAFi/MEKi would maintain superior ERK pathway inhibition in … ERK reactivation and …

250 天前 - … the activation of the ERK pathway. Therefore, we explored … SHP2 inhibitor decreases
the adaptive ERK reactivation … to the versatile efficacy of SHP2 inhibition in multiple AML …

277 天前 - … (ON) inhibitor RM-029 still resulted in RAS pathway reactivation. … pathway. In an
inflamed, anti-PD-1 sensitive mouse model of NSCLC, KRAS G12C (ON) and SHP2 inhibitors …

277 天前 - … of cell viability than the KRAS G12C (OFF) inhibitor MRTX849 in both … ) inhibitor
RM-029 still resulted in RAS pathway reactivation. Addition of RMC-4550 blocked RAS pathway…

285 天前 - … on BCR::ABL1 reactivation, the mechanisms of … inhibit this pathway by blocking
BCR::ABL1 and inducing apoptosis in CML cells. However, the activation of the RAS pathway …