… putida mt-2. While XylR, the chief TF of this system, … signal specificity of a given regulatory
device depends not only on the TF involved but also on TF connectivity to upstream signals …

… in MT1 and MT2 melatonin receptor signaling through G protein … In this review signaling
pathways for MT1 and MT2 … properties (affinity, efficacy, selectivity, specificity) of the ligands and …

… 29425 A number of diverse signaling pathways canbe ac- … However, the In terms of the
plasticity of signal transduction, … well under- determinants of signaling specificity. The adrenergic …

… signaling specificity be approached, modeled and quantified? Theoretical studies of signaling
specificity … ] that the biological notion of 'signaling specificity' corresponds to two related yet …

… Melatonin produces a long-lasting sensitization of adenylyl cyclase and thus amplifies cyclic
AMP signaling when melatonin levels decline at dawn. This action of melatonin amplifies …

… dawn via activation of MT 2 melatonin receptor signaling. … In this report, the specificity of
labeling of each probe to the … and rigorously controlled for specificity by competition experiments. …

… A signal for a cell is whatever is recognized as such by a receptor that … signal. A receptor is
the structure that recognizes and reacts to the signal and interprets the specificity of the signal. …

… for responding to a diverse range of signals [2, 3]. The faithful coupling of input signals to
desired cellular outputs requires tight enforcement of pathway specificity [4]. Here we review …

… of cytosolic cAMP levels and inhibition of protein kinase A signaling pathway (13). Interestingly,
other signaling pathways have also been assigned to melatonin receptor activation; one …

… functional metal specificity of HpCdMT … MT isoforms from a number of snail species revealed
that they possess an unspecific and two metal-specific MT isoforms, whose metal specificity …