Regulation of liver inflammatory injury by signal transducer and activator of transcription-6

A Kato, H Yoshidome, MJ Edwards… - The American journal of …, 2000 - Elsevier
Signal transducer and activator of transcription-6 (STAT6) is … ) of STAT6 in liver during
inflammation induced by ischemia/… in the regulation of the acute inflammatory response in liver. …

[HTML][HTML] Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target

H Wang, F Lafdil, X Kong, B Gao - International journal of biological …, 2011 - ncbi.nlm.nih.gov
… In this review, we highlight recent advances of STAT3 signaling in liver injury, steatosis,
inflammation, regeneration, fibrosis, and hepatocarcinogenesis. The cytokines and small …

[HTML][HTML] Signal transducer and activator of transcription 4 in liver diseases

Y Wang, A Qu, H Wang - International Journal of Biological …, 2015 - ncbi.nlm.nih.gov
… documented in liver inflammatory response, liver injury and inhibition of virus replication.
Moreover, the activation of STAT4 was also detected in several models of liver injury including …

[PDF][PDF] Inflammation‐associated interleukin‐6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in …

AM Miller, H Wang, A Bertola, O Park, N Horiguchi… - …, 2011 - Wiley Online Library
… promotes inflammation, whereas inflammation in … -inflammatory cytokine, exacerbates liver
inflammation, steatosis, and hepatocellular damage in alcoholic and nonalcoholic fatty liver

Cell type–dependent pro-and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury

N Horiguchi, L Wang, P Mukhopadhyay, O Park… - Gastroenterology, 2008 - Elsevier
… In this study, we explored the functions of STAT3 in alcoholic liverinflammation, whereas
in macrophages STAT3 activation inhibits liver inflammation during chronic alcoholic liver

[PDF][PDF] Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice

R Sakamori, T Takehara, C Ohnishi, T Tatsumi… - …, 2007 - Wiley Online Library
inflammatory response leading to multiorgan failure and occasionally death. During this
process, signal transducer and activator of transcription 3 (STAT3) is activated in the liver, but …

[PDF][PDF] Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell–specific signal transducer and activator of …

N Horiguchi, F Lafdil, AM Miller, O Park, H Wang… - …, 2010 - Wiley Online Library
inflammation may attenuate liver necrosis induced by carbon tetrachloride (CCl4) in myeloid-specific
signal transducer … As an important anti-inflammatory signal, conditional deletion of …

[HTML][HTML] Decoding cell death signals in liver inflammation

C Brenner, L Galluzzi, O Kepp, G Kroemer - Journal of hepatology, 2013 - Elsevier
… Of note, the acute phase protein IL-6 has been recently suggested to play a prominent role
in hepatic carcinogenesis as it activates signal transducer and activator of transcription 3 (…

[HTML][HTML] … protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of …

A Nerstedt, A Johansson, CX Andersson, E Cansby… - Diabetologia, 2010 - Springer
… and lipid oxidation in the liver [7], also inhibits cytokine-induced inflammation in this tissue. …
point of convergence of metabolic and inflammatory signals in the liver, and may provide a …

[PDF][PDF] Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity

H Wang, O Park, F Lafdil, K Shen, N Horiguchi… - …, 2010 - Wiley Online Library
… To further understand the interaction of myeloid and hepatic STAT3 in controlling liver
inflammation and regeneration, we also generated hepatocyte-specific STAT3 knockout (…