… Recent progress in our understanding of signal transduction pathways that are activated
during inflammation has led to new targets for anti-inflammatory drugs being explored and new …

… all contribute to inflammation. Increasing efforts are … signaling pathways in inflammatory
diseases like rheumatoid arthritis (RA). In this review we will outline the major signal transduction …

… Although TNFR mediates apoptotic signal transduction, it can transduce intracellular signals
that activate transcription factor nuclear factor κB (NF-κB) by proteolytic breakdown of the …

… The activity of at least 3 transcription factors relevant to inflammatory diseases—AP-1, NF-B, …
in inflammatory diseases (3). MAPK cascades consist of 3- or 4-tiered signaling modules in …

… ( 7 ) Recent progress in our understanding of signal transduction mechanisms of innate
immune systems also provides additional evidence for the link between inflammation and cancer…

… of inflammatory reactions. More than 50 cytokines have been identified, and more and more
has become known about their receptors and signal transduction … in inflammatory disease …

… expressed on cells and tissues and initiate both distinct and overlapping signal transduction
pathways. These diverse signalling cascades lead to a range of cellular responses, which …

… anti-inflammatory drugs acting primarily against pro-inflammatory … agents on alternative
signal transduction pathways. These … diseases in which these alternative factors and signalling …

… This has led to current initiation of clinical trials in inflammatory disease states evaluating …
in inflammatory diseases, here we review current knowledge of the MAP kinase signalling …

… understanding of the signal transduction pathways involved in inflammatory pathology has
… targeting a single signal transduction pathway will be efficacious in many disease states. …