Signal transduction networks: topology, response and biochemical processes
… that is employed in this analysis, network size has limited effects … be generalized to signal
transduction networks of larger size. … relate this analysis to real signal transduction networks we …
transduction networks of larger size. … relate this analysis to real signal transduction networks we …
[HTML][HTML] A computational framework for the topological analysis and targeted disruption of signal transduction networks
MS Dasika, A Burgard, CD Maranas - Biophysical journal, 2006 - cell.com
In this article, optimization-based frameworks are introduced for elucidating the input-output
structure of signaling networks and for pinpointing targeted disruptions leading to the …
structure of signaling networks and for pinpointing targeted disruptions leading to the …
Signal transduction networks in cancer: quantitative parameters influence network topology
DJ Klinke - Cancer research, 2010 - AACR
… Taken together, the simulations suggest that the topology of signal transduction networks …
In summary, these cellular changes can cause abnormal expression of proteins involved in …
In summary, these cellular changes can cause abnormal expression of proteins involved in …
Topological analysis of mass-balanced signaling networks: a framework to obtain network properties including crosstalk
JA Papin, BO Palsson - Journal of theoretical biology, 2004 - Elsevier
… Signal transduction networks have only been studied at a small scale because large-scale …
analysis methods have not been available. Since reconstructions of large signaling networks …
analysis methods have not been available. Since reconstructions of large signaling networks …
Network modeling of signal transduction: establishing the global view
HA Kestler, C Wawra, B Kracher, M Kühl - Bioessays, 2008 - Wiley Online Library
… to analyze and describe such signal transduction networks in … of the topological features of
the MAPK network were found to … be considered in signal transduction networks is redundancy…
the MAPK network were found to … be considered in signal transduction networks is redundancy…
[HTML][HTML] Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks
DC Kirouac, J Saez-Rodriguez, J Swantek… - BMC systems …, 2012 - Springer
… of signal transduction networks, how those networks are … and accurate reconstruction
of network topology. Data on … EGF signalling network, we performed the same analysis on …
of network topology. Data on … EGF signalling network, we performed the same analysis on …
[HTML][HTML] Simulated evolution of signal transduction networks
M Mobashir, B Schraven, T Beyer - PloS one, 2012 - journals.plos.org
… of signal transduction networks due to changes in kinetic parameters and network topology.
… We analyze the effect of strong and weak interactions by simulating SNs evolution for three …
… We analyze the effect of strong and weak interactions by simulating SNs evolution for three …
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction
J Saez‐Rodriguez, LG Alexopoulos… - Molecular systems …, 2009 - embopress.org
… ‐protein signal transduction circuit that mediates immediate‐early signalling downstream of
… (on and off), fitting errors would be too large to distinguish differences in pathway topology. …
… (on and off), fitting errors would be too large to distinguish differences in pathway topology. …
Signal transduction and gene regulation networks
AP Potapov - Analysis of Biological Networks, 2008 - Wiley Online Library
… While the topological analysis of metabolic networks is a well-established field, … signal
transduction networks. Despite of a great body of information about many details of different signal …
transduction networks. Despite of a great body of information about many details of different signal …
Topological peculiarities of mammalian networks with different functionalities: transcription, signal transduction and metabolic networks
B Goemann, E Wingender, AP Potapov - 2011 - publications.goettingen-research …
… The pairwise disconnectivity index as a new metric for the topological analysis of
regulatory networks. BMC Bioinformatics, 9: 227 Potapov AP, Voss N, Sasse N, et al. 2005. …
regulatory networks. BMC Bioinformatics, 9: 227 Potapov AP, Voss N, Sasse N, et al. 2005. …
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