… -TNF-α treatment in patients with and without heart disease and describes the involvement
of TNF-α signaling in a number of animal models of cardiovascular diseases. We specifically …

… role of TNF-α signaling concerning innate cardiac cellular … TNF-α levels remain markedly
higher in heart failure patients … in heart failure, but that measurement of the levels of TNF-α is …

… like TNFα can impact cardiac function by mediating signals … TRAF2 is the nodal molecule
that mediates beneficial signals … determinant of TNFα response in conditions of heart failure. …

… both TNF receptors are involved in the protective signal transduction cascade. Finally, the
available clinical attempts to antagonize TNFα in cardiovascular disease, notably heart failure, …

… heart failure is always associated with both local and systemic activation of inflammatory
signaling cascades. … could pave the way for innovative therapeutics in patients with heart failure. …

… ischemia/reperfusion injury and heart failure. The formation and release of TNFα and its
downstream signal transduction cascade following activation of its two … Tumor necrosis factor α …

… expression within the myocardium may include inhibiting the synthesis and release of TNF-α
or blocking TNF-α signaling. A number of pharmacological agents are available to block the …

… Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating the …

… heart disease and inflammatory signaling in heart. NO is recognized as a potent anti-inflammatory
molecule, demonstrated to reduce the production of cytokines, prostaglandins and …

… TNF with the severity of chronic heart failure in patients and postulated that TNF may contribute
to the pathogenesis of heart failure… signaling events known to lead to macrophage TNF …