… Patients with rheumatoid arthritis have an increased risk for cardiovascular disease and
anti-TNF alpha therapy seems to be beneficial on the risk of cardiovascular disease. In Crohn's …

… for S1P signaling and vascular tone. In heart failure, tumor necrosis factor-α downregulates
… regulator across several organs, including the heart, lung, and brain, suggesting that it is a …

… levels of TNF-α, IL-6, IL-1, and IL-18 have been described repeatedly in patients with
chronic heart failure, … TNF-α signaling has a more delayed onset of actions, which assists in …

… domain of the membrane receptors, namely soluble TNF receptors. TNF-α was first
supposed to be linked with congestive heart failure (CHF) on a cachexia-inducing basis. In …

… Experimental evidence demonstrating involvement of IL-6 signaling in the pathogenesis
of heart failure suggests that treatment with tocilizumab may also be effective in …

… showing the role of TNF α as a pathogen in congestive heart failure and the difficulties in …
is the understanding of these signaling molecules in the modulation of stem cell plasticity, …

… in which cytokine tumor necrosis factor α (TNF-α) plays a key … TNF-α is the target of drugs
used for the treatment of some diseases, eg, Infliximab—a monoclonal antibody against TNF…

… appreciation that TNF may have beneficial or deleterious effects in the heart, … of heart
failure and a higher heart failure survival than males. We hypothesized that TNFR1 signaling …

… have been implicated in the loss of contractile function during heart failure (HF). Moreover, …
the role of TNF- signaling and are consistent with the concept that cardiac hypertrophy seems …

… Additionally, a growing body of studies link TLR signaling to adverse cardiac remodeling …
These TLRs may represent novel targets for intervention in ischemic heart disease, as …