… During myocardial ischemia or in heart failure, myocardial and/or serum TNF-α levels are
increased and are causally involved in contractile dysfunction. By contrast, low physiological …

… of TNF-α signaling is the neutralization of TNF-α by its … has been observed with reports that
TNFα can both induce … responses to TNFα have been observed in other tissues, as TNF-α has …

… for the development and progression of heart failure and could have therapeutic implications.
IL-6 mediates its effects in the myocyte through the gp130 signaling pathway 17 (Figure 1), …

… TNF during acute ischemia, heart failure, or other conditions in which TNF may play a role in
cardiac … Since the true concentration of TNF in heart tissue is unknown, one cannot know ex…

… who reported elevated levels of tumor necrosis factor α (TNFα) in patients with HF with reduced
ejection fraction [8]. Numerous studies have demonstrated that patients with HF exhibited …

… mellitus (DM) and cardiovascular disease. For decades, both … , diabetes, and cardiovascular
disease. However, the … as in their intracellular signaling pathways. Upon stimulation, …

… to heart failure. We observed altered gene expression consistent with a proapoptotic shift in
the TNF-α signaling pathway. Specifically, we found decreased expression of TNF-α- and NF…

… of TNFα and interestingly are also highly responsive to TNFα. Aberrant TNFα production and
TNF receptor signaling … of several diseases, including rheumatoid arthritis, Crohn’s disease, …

… in the progression of heart failure and cardiovascular disease. … been used and studied in
heart failure disease progression. … cells and inflammatory signaling in cardiovascular diseases, …

… Tumor necrosis factor α (TNFα) plays a major role in chronic heart failure, signaling through
… functional role and signaling pathways related to TNFR1 and TNFR2 in cardiac myocytes. In …