… 950 patients with coronary artery disease. They found that the plasma IL-6 levels of patients
… SOCS-3 functions both as an LPS signal inhibitor and as a negative feedback regulator of IL…

… for cardiac-restricted overexpression of TNF-α developed … eventually heart failure confirms
the suspicion that TNF-α plays … signaling events that underlie TNF-α expression in heart cells. …

… in patients with premature coronary heart disease (CHD). Experimental studies suggest that
the cytokine tumor necrosis factor ~ (TNF~) … The present study examined whether TNF~ is …

… Thus, cardiomyocyte apoptosis may be a determinant element in the transition between
compensatory cardiac hypertrophy and heart failure [Citation49]. Two general pathways have …

… mediated signaling … signaling mechanisms, TNF/TNF receptor family and TWEAK/Fn14
axis, and some micro-RNAs as candidate target pathways in pathogenesis of heart failure. These …

… Although TNFR2 is known to promote T-cell proliferation, we show that the TNF-α–TNFR1
axis regulates proapoptotic signals in T cells. To our knowledge, this is the first study to show …

… , whereas ablation of TNFR1 blunts heart failure and improves survival. Signaling via
TNFR2 may play a cardioprotective role in the pathogenesis of cytokine-mediated heart failure. …

… In the present study, we provide evidence that TNF-α, signaling through TNFR1/p55, is
an inducer of cell activation, myocarditis development, and heart tissue damage during …

… the heart, and its complex and divergent downstream signalling … of signals from TNF-R2
and its role in TNF-α signalling are … In the heart the negative inotropic activity of TNF-α appears …

… TNF-α reduced superoxide production in Lepr db mice. In conclusion, our results indicate that
the interaction between NF-κB and TNF-α signaling … with cardiovascular disease. Many of …